• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Conference on Na/Ca Exchange >Involvement of the Potassium-Dependent Sodium/Calcium Exchanger Gene Product NCKX2 in the Brain Insult Induced by Permanent Focal Cerebral Ischemia
【24h】

Involvement of the Potassium-Dependent Sodium/Calcium Exchanger Gene Product NCKX2 in the Brain Insult Induced by Permanent Focal Cerebral Ischemia

机译：依赖于钾依赖性钠/钙交换剂基因产物NCKX2在受永久局灶性脑缺血诱导的脑损伤中的患者

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sodium/calcium exchangers are neuronal plasma membrane transporters, which by coupling Ca~(2+) and Na~+ fluxes, may play a relevant role in brain ischemia. The exchanger gene superfamily comprises two arms: the K~+-independent (NCX) and K~+-dependent (NCKX) exchangers. In the brain, three different NCX (NCX1, NCX2, NCX3) and three NCKX (NCKX2, NCKX3, NCKX4) family members have been described. Up to now, no sutides about the role played by NCKX proteins in cerebral ischemia have been published. The aim of the present study was to investigate the role of NCKX2 in an in vivo model of permanent middle cerebral artery occlusion (pMCAO). The role of this protein in the development of ischemic damage was assessed by knocking-down its expression with an antisense oligodeoxynucleotide (AS-ODN), intra-cerebroventricularly infused by an osmotic minipump for 48 h, starting from 24 h before pMCAO. The results showed that NCKX2 knocking-down by using antisense strategy increased the extent of the ischemic lesion. The results of this study suggest that NCKX2 could exert a neu-roprotective effect during ischemic injury.
机译：钠/钙交换剂是神经元质膜转运蛋白，其通过偶联Ca〜（2+）和Na〜+助熔剂，可能在脑缺血中发挥相关作用。交换器基因超家族包括两个臂：K〜+依赖性（NCX）和K〜+依赖性（NCKX）交换剂。在大脑中，已经描述了三种不同的NCX（NCX1，NCX2，NCX3）和三个NCKX（NCKX2，NCKX3，NCKX4）家庭成员。到目前为止，没有发表关于Nckx蛋白在脑缺血中发挥的作用的锡卫生。本研究的目的是探讨nckx2在永久性中脑动脉闭塞（PMCAO）的体内模型中的作用。通过用反义寡脱氧核苷酸（AS-ODN）敲击其表达来评估该蛋白质在缺血性损伤中的作用，通过渗透寡核苷酸的脑内注入48小时，从24小时开始，从PMCAO之前开始。结果表明，通过使用反义策略的NCKX2敲低增加了缺血性病变的程度。本研究结果表明，NCKX2在缺血性损伤期间可以发挥Neu-Ropotective效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号