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Effect of multivitamin on vitamin D status and heel ultrasound bone density in Australian aged care residents

机译:多种维生素对维生素D状态的影响和澳大利亚老年护理居民的鞋跟超声骨密度

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Purpose: To determine, in a group of Australian, aged care residents, if a multivitamin [MV, containing 200 IU (5 礸) cholecalciferol] supplementation for 6 months, improves nutritional status and quantitative heel ultrasound. Principal results: Ninety-two subjects [mean (S.D.) age 80-0 years (10.1 years)] completed the 6-month, randomized, double-blind, placebo (P)-controlled study. At the end of the study, those taking the MV (h=49) had a mean+-S.E.M. of 33.4+-2.6 nmol/l higher serum 25(OH)D concentration vs. P (n=43, p<001), where 77% of subjects had levels > 50 nmol/l vs. only 10% (P<.00l) taking the P. The MV group also had higher serum folate (+13.4+-2.8 nmol/l) and vitamin B12 concentrations (163.5 +-40.3 pmol/1) vs. P (all P<.001). After adjusting for baseline ultrasound values, heel ultrasound increased in the MV group by a mean+-S.E.M. of +2.7+-2.2 dB/ MHz vs. a fall in the P group (-2.5+-2.0 dB/MHz, -P=.O41). Conclusions: In this nutritionally vulnerable group, multivitamin supplementation improved serum 25(OH)D, vitamin B12 and folate concentrations, which may reduce the risk of micronutrient-related diseases. Multivitamin supplementation appeared to have a positive effect on bone quality which may reduce the risk of osteoporosis.
机译:目的:确定,在一组澳大利亚,老年护理居民中,如果多种维生素[MV,含有200IU(5次)胆总管]补充6个月,可提高营养状况和定量鞋跟超声。主要结果:九十二对象[均值(S.D.)年龄80 - 0年(10.1岁)]完成了6个月,随机,双盲,安慰剂(P) - 控制研究。在研究结束时,那些服用MV(H = 49)的人有一个平均+ -S.E.M。 33.4 + -2.6 nmol / l高血清25(OH)D浓度与p(n = 43,p <001),其中77%的受试者具有水平> 50nmol / L与10%(P <。 00l)服用p.MV组还具有更高的血清叶酸(+ 13.4±2.8诺米酚/ L)和维生素B12浓度(163.5±40.3 pmol / 1)与p(所有P <.001)。在调整基线超声值后,鞋跟超声通过平均+ -S.E.M在MV组中增加。 + 2.7 + -2.2dB / MHz与P组下降(-2.5 + -2.0dB / MHz,-P = .O41)。结论:在这种营养脆弱的群体中,多种维生素补充改善血清25(OH)D,维生素B12和叶酸浓度,这可能降低微量营养素相关疾病的风险。多种维生素补充似乎对骨质质量产生了积极影响,这可能降低骨质疏松症的风险。

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