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首页> 外文会议>International Symposium on the Nutrition of Herbivores >Effect of cysteamine on mucosa regeneration of intestinal trauma goats and on duodenal cell proliferation of cows in primary culture
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Effect of cysteamine on mucosa regeneration of intestinal trauma goats and on duodenal cell proliferation of cows in primary culture

机译：半胱胺对肠创伤山羊粘膜再生的影响及原发性培养中奶牛十二指肠细胞增殖

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Eight postoperative goats with intestinal trauma were orally supplemented with cysteamine hydrochloride (CS) in a dose of 45 (Exp, n=4) or 0 mg·kg-1BW per day (Con, n=4), respectively, to investigate the effects of CS on mucosal morphology. The duodenal epithelial cells of cows (n=3) were cultured to determine DNA synthesis and anti-oxidation capacity. Compared with Con the villous height in duodenum (DM) and in proximal jejunum (PJ) was enhanced significantly (P<0.05) in Exp, the crypt depth also increased in these two tissues (P=0.08, P=0.06). The RNA/ DNA ratio decreased in Exp for DM (P=0.10) and for PJ (P<0.05). CS also enhanced mucosal y-glutamyl transferase activity in the DM or PJ (P<0.05), and the alkaline phosphatase activity in the PJ (P=0.08). These data indicated that CS induced mucosa hyperplasia rather than hypertrophy in DM and PJ. This was supported by in vitro experiment, in which CS stimulated DNA synthesis and enhanced total anti-oxidation capacity and the intracellular glutathione concentration in cultured duodenal cells of cows (P<0.05).
机译：八个患有肠外创伤的牙科山羊口服盐酸胺（Cs）的盐酸胺（CS）分别为每天45（Exp，N = 4）或0mg·Kg-1bw（Con，N = 4），以研究效果作者：王莹，CS对粘膜形态学。培养奶牛（n = 3）的十二指肠上皮细胞以确定DNA合成和抗氧化能力。与Duexenum（DM）和近端Jejunum（PJ）中的绒毛高度显着增强（P <0.05），在这两种组织中也增加了（P = 0.08，P = 0.06）。对于DM（P = 0.10）和PJ（P <0.05），RNA / DNA比率降低。 CS还增强了DM或PJ（P <0.05）中的粘膜Y-戊酰胺转移酶活性，以及​​PJ中的碱性磷酸酶活性（P = 0.08）。这些数据表明，CS诱导粘膜增生而不是DM和PJ中的肥大。这是通过体外实验支持的，其中CS刺激DNA合成和增强的总抗氧化能力和培养的十二指肠细胞中的细胞内谷胱甘肽浓度（P <0.05）。

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