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Morphological Peculiarities of Heart and Coronory Vessels Damage in Adults with Type 2 Diabetes Mellitus

机译:患有2型糖尿病的成人损伤的心脏和轴血管的形态学特性

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We revealed morphological peculiarities of myocardium and coronary vessels damage in type 2 diabetes mellitus (DM) patients without clinical signs of atherosclerosis and ischemic heart disease, in particular, a pronounced fatty degeneration of cardiomyocytes, accumulation of alpha - and beta-glycogen in them, micromitochondriosis with marked polymorphism, myofibril lysis, sarcoplas-mic reticulum defects, mitochondria destruction with crysts loss, apoptosis signs as well as arterioles and small and medium arteries changes, namely, a marked edema of endotheliocytes, occurrence of fenestrated capillaries that are not normally characteristic of myocardium, and hypertrophy of smooth muscle cells. These changes were responsible for decrease in useful heart work and disturbed coronary vessels function.
机译:我们揭示了2型糖尿病(DM)患者的心肌和冠状动脉血管损伤的形态特性,但没有动脉粥样硬化和缺血性心脏病的临床迹象,特别是心肌细胞的明显脂肪变性,α和β-糖原的积累,微量粒度具有显着的多态性,肌纤维裂解,生物纤维 - 麦克风观察缺陷,线粒体破坏,具有脱裂,细胞凋亡标志以及动脉和中小型动脉变化,即内皮细胞的标记水肿,未发生的毛细血管的发生,这些毛细血管不是通常特征的光学肌动脉细胞的肥大。这些变化负责有用的心脏工作和冠状动脉血管功能的减少。

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