Naringenin Exerts Its Anti-Tumor Effect Via Antiangiogenesis

机译：Naringenin通过抗脑发生施加抗肿瘤作用

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Naringenin inhibited the proliferation and induced apoptosis in human non-small cell lung carcinoma (A549) cells and human umbilical vein en-dothelial (ECV304) cells. The development of microvessel structures in ECV304 cells and VEGF mRNA expression were inhibited by naringenin in a dose-dependent manner. Naringenin was also able to prevent A549 cell migration and invasion in vitro and to inhibit Lewis Lung Carcinoma (LLC) growth in the subcutaneous mouse model. Naringenin (4,5,7-trihydroxyflavanone), a natural predominant flavanone, has a wide range of pharmacology properties, such as anticancer [1], anti-mutagenic [2], and anti-inflammatory [3]. However, its mechanisms by which inhibits tumor growth remain unclear. Here, we report for the first time that naringenin exerts its anti-tumor effect by the inhibition of angiogenesis.

机译：Naringenin抑制人非小细胞肺癌（A549）细胞和人脐静脉栓塞（ECV304）细胞的增殖和诱导的细胞凋亡。纳林尼以剂量依赖性方式抑制ECV304细胞和VEGF mRNA表达中的微血管结构的发展。 Naringenin还能够在体外预防A549细胞迁移和侵袭，并抑制皮下小鼠模型中的Lewis肺癌（LLC）生长。 Naringenin（4,5,7- TrihydroxyFlavanone），一种自然优势黄酮，具有广泛的药理学性质，如抗癌[1]，抗诱变[2]和抗炎[3]。然而，其通过抑制肿瘤生长的机制仍然不清楚。在这里，我们首次报告纳林宁抑制血管生成的抗肿瘤作用。

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《World Congress for Microcirculation》|2007年||共6页
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F. Zhang; G. Du; W. Liang;
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2. Improved performance of naringenin herbosomes over naringenin in streptozotocin- induced diabetic rats: In vitro and in vivo evaluation [J] . Ruthvika Joshi, Ankit P.Laddha, Yogesh A.Kulkarni, 亚太热带生物医学杂志：英文版 . 2021,第009期
3. Cytotoxic, genotoxic and apoptotic effects of naringenin-oxime relative to naringenin on normal and cancer cell lines [J] . Abdurrahim Kocyigit, Ismail Koyuncu, Murat Dikilitas, 亚太热带生物医学杂志（英文版） . 2016,第010期
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Naringenin Exerts Its Anti-Tumor Effect Via Antiangiogenesis

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