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首页> 外文会议>World Congress for Microcirculation >Relationship between plasma von willebrand factor, fibrinogen and flow mediated vasodilatation in hypertensive patients
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Relationship between plasma von willebrand factor, fibrinogen and flow mediated vasodilatation in hypertensive patients

机译：血浆von willebrand因子，纤维蛋白原和流量介导的高血压患者血管扩张的关系

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Haemostatic markers such as fibrinogen and von Willebrand factor (vWf) are involved in the development and progression of vascular disease. Endothelial dysfunction can be quantified by measuring homeostatic markers or by assessing flow mediated vasodilatation (FMD) in the brachial artery. The aim of this study was to compare the levels of vWF, fibrinogen and brachial FMD in hypertensive patients with and without atherogenic dyslipidemia and healthy controls and to study the relation between the mentioned endothelial dysfunction markers.We found statistically significant higher values for vWf and fibrinogen in hypertensive patients with and without atherogenic dyslipidemia compared to healthy controls (p<0.001). Endothelium-dependent vasodilatation was significantly impaired in hypertensive patients with and without atherogenic dyslipidemia (p<0.001).The measurement of brachial FMD and plasma homeostatic markers can be useful diagnostic tools to evaluate microvascular dysfunction in hypertensive patients.
机译：血频蛋白原和von Willebrand因子（VWF）的血管科标记涉及血管疾病的开发和进展。通过测量稳态标记或通过评估肱动脉中的流动介导的血管舒张（FMD），可以通过测量内皮功能障碍。本研究的目的是将VWF，纤维蛋白原和肱骨腺癌的水平进行比较，患有血肿性血脂血症和健康对照组的高血压患者，并研究所述内皮功能障碍标志物之间的关系。我们发现VWF和纤维蛋白原的统计学显着较高的值与健康对照相比，在高血压患者和无血肿性血脂血症（P <0.001）。依赖于血管生殖血脂血症的高血压患者（P <0.001），内皮依赖性血管抑制显着损害。肱臂FMD和血浆稳态标志物的测量可以是有用的诊断工具，以评估高血压患者微血管功能障碍的诊断工具。

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