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Preparation and characterization of doxorubicin-loaded magnetic anticancer nanoparticles

机译:加载多柔比蛋白磁性抗癌纳米粒子的制备与表征

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Doxorubicin(ADM)-loaded magnetic anticancer nanoparticles, using Fe3O4 as core,doxorubicin as model drug and polyvinylpyrrolidone(PVP) as matrix, were prepared by inverse emulsion polymerization. The experimental results showed that the average diameter of Fe3O4 particles was 19.8nm.The X-ray diffraction indicated that the prepared Fe3O4 particle was pure cubic Fe3O4.The results obtained by SEM showed the magnetic nanoparticles under optimal operating condition had a smooth spherical surface, LLS showed an average size of 78.7nm. And IR results demonstrated that they consisted of ADM,PVP and Fe3O4.
机译:通过逆乳液聚合制备使用Fe3O4作为核心,多柔比蛋白作为模型药物和聚乙烯吡咯烷酮(PVP)作为基质的磁性抗癌纳米粒子。实验结果表明,Fe3O4颗粒的平均直径为19.8nm。X射线衍射表明,制备的Fe3O4颗粒是纯度Fe3O4的。通过SEM获得的结果在最佳操作条件下显示出磁性纳米颗粒具有光滑的球形表面, LLS显示平均大小为78.7nm。 IR结果表明,它们由ADM,PVP和Fe3O4组成。

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