...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug development and industrial pharmacy >Theranostic nanoparticles based on magnetic nanoparticles: design, preparation, characterization, and evaluation as novel anticancer drug carrier and MRI contrast agent'
【24h】

Theranostic nanoparticles based on magnetic nanoparticles: design, preparation, characterization, and evaluation as novel anticancer drug carrier and MRI contrast agent'

机译：基于磁性纳米粒子的治疗纳米粒子：设计，制备，表征和评估为新的抗癌药物载体和MRI造影剂'

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this work, we reported the synthesis of curcumin (CUR)-loaded hydrophilic and hydrophobic natural amino acids (AAs)-modified iron oxide magnetic nanoparticles (IONPs). Two types of AAs, l-lysine (Lys) and l-phenylalanine (PhA), were selected to study their effects on loading capacity, release profile of CUR, biocompatibility, and anticancer activity. CUR-loaded AAs-modified IONPs (F@AAs@CUR NPs) were characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), and transmission electron microscopy (TEM) techniques. Next, the various kinetic equations were fitted to the release data of CUR from F@Lys@CUR NPs and F@PhA@CUR NPs. Additionally, hemolysis test and MTT assays on HFF-2 and HEK-293 cell lines were performed for determination of biocompatibility of AAs-coated IONPs. Finally, the anticancer activity of F@AAs@CUR NPs examined on MCF-7 breast cancer cell line. The results indicate that these nanocarriers are nontoxic and biocompatible and also F@AAs@CUR NPs are suitable carriers for delivery of curcumin and even other hydrophobic drugs. Also, the MRI training established the effectiveness of IONPs as contrast agent for the revealing of tumor as evidenced from the phantom images as well as higher T2 relaxivity
机译：在这项工作中，我们报道了姜黄素（CUR）加载的亲水和疏水天然氨基酸（AAS）制氧化铁磁性纳米颗粒（IONP）的合成。选择两种类型的AAs，L-赖氨酸（Lys）和L-苯丙氨酸（PHA），以研究它们对负载能力，Cur，生物相容性和抗癌活性的释放曲线的影响。 CUR负载的AAS改性IONP（F @ AAS @ Cur NPS）的特征在于X射线衍射（XRD），热重分析（TGA），傅里叶变换红外光谱（FTIR），振动样品磁力计（VSM）和透射电子显微镜（TEM）技术。接下来，将各种动力学方程装配到来自F @ Lys @ Cur NPS和F @ Cur NPS的Cur的释放数据。另外，进行HFF-2和HEK-293细胞系上的溶血试验和MTT测定，用于测定AAS涂覆的IONP的生物相容性。最后，在MCF-7乳腺癌细胞系上检查F @ AAS @ Cur NPS的抗癌活动。结果表明，这些纳米载流子是无毒的，并且生物相容性和F @ Aas @ Cur NPS是合适的载体，用于递送姜黄素甚至其他疏水药物。此外，MRI培训建立了IONPS作为造影剂的造影剂，用于揭示肿瘤，从幻像图像中证明以及更高的T2松弛率

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号