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High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases

机译:高海拔肺动脉高压和慢性山病 - 重新评估慢性和亚急性高海拔疾病的共识

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An expert consensus workshop group of the International Society for Mountain Medicine recently proposed a new classification of high altitude diseases. Chronic mountain disease or Monge’s disease was defined as a separate entity on the assumption that pulmonary hypertension was not always identified in these patients. This may have to be revised. Healthy high altitude natives living above 3500 m have pulmonary hypertension and right ventricular hypertrophy associated to hypoxemia and polycythemia. There is a direct relation between the level of altitude and the degree of pulmonary hypertension, with exception of Tibetan natives who have the oldest altitude ancestry. After many years of residence at high altitude, some healthy highlanders may lose their adaptation and develop chronic mountain sickness, a clinical entity associated with marked hypoxemia, exaggerated polycythemia and increased pulmonary hypertension, evolving in some cases to heart failure. Other chronic high altitude diseases, such as high altitude heart diseases described in China and high altitude cor pulmonale described in Kyrgystan, have a clinical picture similar to chronic mountain sickness, with lesser degrees of hypoxemia and polycythemia which, however, are often measured at lower levels during the recovery. A systematic review of world-wide literature has demonstrated that pulmonary hypertension is a common feature, in different magnitudes, to healthy highlanders and high altitude diseases. Differences of mean pulmonary artery pression amongst chronic mountain sickness, high altitude heart diseases and high altitude cor pulmonale are no significant and it is highly probable that they are the same disease with different shades. Therefore, chronic high altitude diseases should be integrated in one group and consequently, any scoring system should be applicable to all of them. On the other hand, subacute mountain sickness and high altitude pulmonary edema, clinical entities with a distinct time course, should be considered separately.
机译:国际社会为山医学的专家共识车间小组最近提出的高海拔疾病的一种新的分类。慢性高原病或蒙赫病被定义为这样的假设肺动脉高压并非总是在这些患者中确定一个独立的实体。这可能需要修订。健康生活上面3500米高海拔地区的当地人有肺动脉高压和相关的低氧血症和红细胞增多症右心室肥厚。有高度的水平和肺动脉高压的程度之间有直接的关系,与西藏本地人谁拥有最古老的祖先高度的例外。经过多年居住在高海拔地区,一些健康的高地可能会失去他们的适应和发展为慢性高山病,注明低氧血症,夸张红细胞增多症和增加肺动脉高压相关的临床实体,在某些情况下,不断发展的心脏衰竭。其它慢性高原病,如高海拔心脏疾病在中国和吉尔吉斯描述高空肺心病所描述的,具有临床表现类似于慢性高原病,与其中,但是,通常在较低的测得较小程度的低氧血症和真性红细胞增多的在恢复期间的水平。世界范围内的文献的系统综述表明,肺动脉高压是一个共同的特点,在不同的大小,健康的高地和高原疾病。平均肺动脉PRESSION其中包括慢性高原病,高原心脏疾病和高海拔肺心病的差异是不显著,这是他们很可能是同病不同的色调。因此,慢性高原病应被集成在一个基团,并因此,任何评分系统应当适用于所有这些。在另一方面,亚急性高山病和高原肺水肿,具有鲜明的时间过程的临床实体,应单独考虑。

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