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An Improved In Silico Algorithm for Output Visualization of DNA Computing based on Real-Time PCR

机译：基于实时PCR的DNA计算输出可视化的硅算法改进

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In the previous paper, a readout approach for the Hamiltonian Path Problem (HPP) in DNA computing based on the real-time polymerase chain reaction (PCR) was proposed. Based on this approach, real-time amplification was performed with the TaqMan probes and the TaqMan detection mechanism was exploited for the design and development of the proposed readout approach. The readout approach consists of two steps: real-time amplification in vitro using TaqMan-based real-time PCR, followed by information processing in silico to assess the results of real-time amplification, which in turn, enables extraction of the Hamiltonian path. The in silico information processing consists an algorithm to extract the Hamiltonian path based on result of in vitro real-time PCR experiment. However, this algorithm indirectly shows the Hamitonian path by only showing the location of each node for the HPP. Thus, in this paper, we modified the previous in silico algorithm such that the Hamiltonian path can be viewed directly after the in silico information processing of the TaqMan reactions based on real-time PCR is implemented. The modified algorithm can be easily implemented in the computerized application.
机译：在前面的纸张，用于DNA汉弥尔顿路径问题（HPP）的读出方法计算基于所述实时聚合酶链式反应（PCR）中提出的。基于这种方法，利用Taqman探针进行实时放大，利用Taqman检测机制进行建议读出方法的设计和开发。读出方法包括两个步骤：在使用基于TaqMan的实时PCR，随后信息处理在计算机芯片上，以评估实时扩增，这又使得能够汉弥尔顿路径的提取结果体外实时扩增。的在计算机芯片上的信息处理由一个算法来提取基于体外实时PCR实验的结果汉弥尔顿路径。然而，该算法间接示出了由仅表示为HPP每个节点的位置的哈密顿路径。因此，在本文中，我们修改在硅片算法先前使得汉弥尔顿路径可以直接基于PCR实现实时的TaqMan反应的在计算机芯片上的信息处理后观看。修改后的算法可以在计算机化应用容易地实现。

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