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Implementing Tuberculosis Screening Programs in Difficult to Access Worker Populations

机译:实施结核病筛查计划难以进入工人群体

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For more than 90 years the best test available to identify people with TB infections has been the tuberculin skin test (TST). This test requires intra-dermal injection of purified protein derivative (PPD) derived from the TB bacteria followed by observation of the injection site by a trained skin test reader between 48 and 72 hours after injection. Two clinical visits are required in a 72 hour period and for many petroleum workers in remote locations (precisely those areas where TB prevalence is highest) this is impractical. As a result, many workers who have skin tests are advised on how to “self-read” the results – a practice without any proven reliability or validity. Self-assessments of tuberculin test results, if accurate, could enhance tuberculosis screening efforts by reducing the need for follow-up visits for skin test reading (1). The TST also has other limitations, including false positive test results in individuals who were vaccinated with BCG and in individuals who have infections not related to Mycobacterium tuberculosis (2), digit preference by TST readers, and false negative results in people with immune systems disorders like HIV, diabetes, and those on treatment with systemic steroid medications.
机译:超过90年的最佳测试可用于识别TB感染的人是结核菌素皮肤测试(TST)。该试验需要衍生自Tb细菌的纯化蛋白质衍生物(PPD)的纯化蛋白质衍生物(PPD),然后通过培训的皮肤测试读取器观察注射后48至72小时的注射部位。在72小时内需要两种临​​床访问,并且在远程位置的许多石油工人(准确地说,TB患病率最高的区域)这是不切实际的。因此,建议许多有皮肤测试的工人如何“自我读取”结果 - 一种没有任何证明可靠性或有效性的练习。结核病检测结果的自我评估,如果准确,可以通过减少对皮肤测试阅读的需要进行后续访问(1)来增强结核病筛选努力。 TST还具有其他限制,包括用BCG接种的个体和具有与结核分枝杆菌(2)无关的个体接种的个体中的误报结果,并且通过TST读者的数字偏好,免疫系统患者的假阴性结果像艾滋病毒,糖尿病和系统性类固醇药物治疗的那样。

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