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Thromboresistant Reservoir Technologr Based Sirolimus Eluting Stent with Bound Heparin Surface

机译：基于血栓储层的血栓储层肌肉毒素用结合的肝素表面洗脱支架

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Heparin is a naturally occurring anticoagulant. Heparin-containing coatings on various medical devices including coronary stents have been well established as effective thromboresistant surfaces. In this study, we characterized a surface-bound heparin coating and investigated its potential to further enhance the thromboresistance of a next generation NEVO~(TM)stent that releases sirolimus from PLGA and sirolimus matrix filled reservoirs that occupy only 25% of the stent surface, while a non-elutable heparin coating covers the remaining bare metal surface.

机译：肝素是天然存在的抗凝血剂。含肝素的涂料在包括冠状动脉支架的各种医疗装置上，已经很好地建立了有效的血栓形成表面。在该研究中，我们表征了表面结合的肝素涂层，并研究了其进一步增强了从PLGA和西罗莫司填充储存器的下一代Nevo〜（TM）支架的血栓抑制剂的潜力，该储存器仅占据25％的支架表面的储存器，而非可剥离的肝素涂层覆盖剩余的裸金属表面。

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《BioInterface Symposium and Workshop》|2009年||共1页
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Cheng Li;
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原文格式 PDF
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中图分类 R318.08-532;
关键词
coatings; anticoagulant; enhance;

机译：涂料;抗凝剂;增强;

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专利

1. A novel polymer-free paclitaxel-eluting stent with a nanoporous surface for rapid endothelialization and inhibition of intimal hyperplasia: Comparison with a polymer-based sirolimus-eluting stent and bare metal stent in a porcine model [J] . Journal of biomedical materials research, Part A . 2011,第4期

机译：新型无聚合物紫杉醇洗脱支架，具有纳米孔表面，可快速内皮化和抑制内膜增生：在猪模型中与基于聚合物的西罗莫司洗脱支架和裸金属支架的比较
2. Comparison of zotarolimus-eluting stents with sirolimus- and paclitaxel-eluting stents for coronary revascularization: the ZEST (comparison of the efficacy and safety of zotarolimus-eluting stent with sirolimus-eluting and paclitaxel-eluting stent for coronary lesions) randomized trial. [J] . Park DW, Kim YH, Yun SC, Journal of the American College of Cardiology . 2010,第15期

机译：佐他莫司洗脱支架与西罗莫司洗脱支架和紫杉醇洗脱支架在冠状动脉血运重建中的比较：ZEST（佐罗莫司洗脱支架与西罗莫司洗脱支架和紫杉醇洗脱支架治疗冠状动脉病变的疗效和安全性比较）随机试验。
3. Comparison of zotarolimus-eluting stents with sirolimus- and paclitaxel-eluting stents for coronary revascularization: the ZEST (comparison of the efficacy and safety of zotarolimus-eluting stent with sirolimus-eluting and paclitaxel-eluting stent for coronary lesions) randomized trial. [J] . Park DW, Kim YH, Yun SC, Journal of the American College of Cardiology . 2010,第15期

机译：佐他莫司洗脱支架与西罗莫司洗脱支架和紫杉醇洗脱支架在冠状动脉血运重建中的比较：ZEST（佐罗莫司洗脱支架与西罗莫司洗脱支架和紫杉醇洗脱支架治疗冠状动脉病变的疗效和安全性比较）随机试验。
4. Thromboresistant Reservoir Technologr Based Sirolimus Eluting Stent with Bound Heparin Surface [C] . Cheng Li BioInterface Symposium and Workshop . 2009

机译：基于血栓储层的血栓储层肌肉毒素用结合的肝素表面洗脱支架
5. Preclinical and Clinical Evaluation of Biodegradable Polymer Coated Sirolimus Eluting Coronary Stents. [D] . Thakkar, Ashok S. 2011

机译：可生物降解的聚合物涂层西罗莫司洗脱冠状动脉支架的临床前和临床评估。
6. Open-labeled randomized controlled trial to evaluate the 1-year clinical outcomes of polymer-free sirolimus-eluting coronary stents as compared with biodegradable polymer-based sirolimus-eluting coronary stents [O] . Sunitha Viswanathan, Kiran Gopinath, George Koshy, 2018

机译：开放标签的随机对照试验用于评估无聚合物西罗莫司洗脱冠状动脉支架与可生物降解的基于聚合物的西罗莫司洗脱冠状动脉支架相比的1年临床疗效
7. Comparison of Zotarolimus-Eluting Stents With Sirolimus- and Paclitaxel-Eluting Stents for Coronary Revascularization The ZEST (Comparison of the Efficacy and Safety of Zotarolimus-Eluting Stent with Sirolimus-Eluting and PacliTaxel-Eluting Stent for Coronary Lesions) Randomized Trial [O] . Park Duk-Woo, Kim Young-Hak, Yun Sung-Cheol, 2010

机译：佐他莫司洗脱支架与西罗莫司和紫杉醇洗脱支架用于冠脉血运重建的比较ZEST（佐他莫司洗脱支架与西罗莫司洗脱支架和帕克他赛尔洗脱支架治疗冠状动脉病变的疗效和安全性比较）随机试验

Thromboresistant Reservoir Technologr Based Sirolimus Eluting Stent with Bound Heparin Surface

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