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首页> 外文会议>Symposium on Mechanical Behavior of Biological Materials and Biomaterials >Zone-Specific Changes in Mieromeehanical, Biochemical, and Structural Properties in Articular Cartilage from a Rabbit Joint Flexion Model
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Zone-Specific Changes in Mieromeehanical, Biochemical, and Structural Properties in Articular Cartilage from a Rabbit Joint Flexion Model

机译：兔关节屈曲模型的关节软骨中的甲状腺肿，生化和结构特性的特异性变化

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摘要

Metacarpophalangeal (MCP) joint proximal bone-cartilage specimens from the fourth digit were collected from repetitively flexed and non-flexed (control) paws of four New Zealand White rabbits. The specimens were cryo-fractured to reveal a sagittal cut containing the cartilage zones of different collagen microstructure. Nanoindentation, Fourier Transform infrared microspectroscopic imaging (FTIRMI), and histology were performed on a region of interest (ROI) -400 microns wide and through the thickness of the cartilage with two goals in mind: (1) to examine the effect of collagen network structure (random in the mid zone versus organized in the deep zone) on the biomechanical and biochemical properties of cartilage; and (2) to understand the changes in these properties due to physical forces. We found that zone microstructure significantly affected the measurement of the local relaxed modulus measured by nanoindentation. The deep zone had a higher modulus than the mid zone (Wilcoxon paired test, p<0.05). We also found that flexion significantly decreased the proteoglycan content in both the mid and deep zones (Wilcoxon paired test, p<0.05), suggesting indirect repetitive loading in the rabbit paw can be damaging to the joint via down regulating proteoglycan synthesis in the mid and deep zone cartilage. This is the first study to simultaneously report the local zone-specific mechanical and biochemical properties in the rabbit joint flexion model.
机译：从四个新西兰白兔的重复弯曲和非弯曲（对照）爪子收集来自第四位的Metacarpophalangeal（MCP）关节骨库标本。 Cryo-Fractured的标本露出含有不同胶原微观结构的软骨区的矢状切口。纳米intentation，傅里叶变换红外线光谱成像（FTIRMI）和组织学在宽的一个感兴趣区域（ROI）-400微米和穿过有两个目标的软骨厚度上进行：（1）检查胶原网络的效果结构（在深处组织的中区与深区的随机）上的软骨生物力学和生化特性; （2）理解由于物理力量导致这些属性的变化。我们发现区域微观结构显着影响了通过纳米狭窄测量的局部松弛模量的测量。深区的模量高于中间区（Wilcoxon配对测试，P <0.05）。我们还发现，屈曲显着降低了中和深区域（Wilcoxon配对试验，P <0.05）中的蛋白单晶糖含量，表明兔爪中的间接重复载荷可以通过下降调节蛋白质面蛋合成来损害关节。深区软骨。这是第一项研究，同时报告兔关节屈曲模型中的局部区域特异性机械和生化特性。

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