Quality Prediction for a Fed-Batch Fermentation Process Using Multi-Block PLS

机译：使用多块PLS对FED批量发酵过程的质量预测

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Quality prediction is usually required for product quality monitoring and setting up control strategy can reduce operating cost and improve production efficiency. Partial least square (PLS) regression is a popular statistical method for predictive modelling. The amount of data measured and stored in a typical indus-trial process is dramatically increased due to the fast development of computer and measuring system. It is hard to analyse all measured data using one matrix for its complexity. Multi-Block PLS model allows the data to be separated into sub-blocks and the sub-blocks can be analysed independently. Data from the fed-batch fermentation process is used to build models. Data is divided by different modes and different phases and model parameters are used to select variables that can be used as good predictors. The new set of data after variable selections is used to build a new model again. In most cases, new models show improved prediction performances compared with results from the conventional method.

机译：产品质量监测和建立控制策略的质量预测通常需要降低运营成本并提高生产效率。部分最小二乘（PLS）回归是一种用于预测建模的流行统计方法。由于计算机和测量系统的快速发展，测量和储存在典型的indus-inst-insial过程中的数据量显着增加。难以使用一个矩阵分析所有测量数据，以实现其复杂性。多块PLS模型允许将要分成子块的数据，并且可以独立地分析子块。来自FED批量发酵过程的数据用于构建模型。数据被不同的模式除以不同的模式，并且使用不同的阶段和模型参数来选择可用作良好预测器的变量。变量选择后的新数据集用于再次构建新模型。在大多数情况下，与传统方法的结果相比，新模型显示出改善的预测性能。

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《EU-Korea Conference on Science and Technology》|2010年||共8页
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Jeong Jin Hong; Jie Zhang;
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中图分类 N-532;
关键词
PLS; Prediction; development;

机译：PLS;预测;发展;

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专利

1. Optimal minimal variation control with quality constraint for fed-batch fermentation processes involving multiple feeds [J] . Yuan Jinlong, Wang Lei, Xie Jun, Journal of the Franklin Institute . 2020,第11期

机译：最佳的最小变化控制，具有涉及多种馈送的膳食批量发酵过程的质量约束
2. Process monitoring and quality variable prediction utilizing PLS in industrial fed-batch cell culture [J] . Gunther JC, Conner JS, Seborg DE Journal of Process Control . 2009,第5期

机译：在工业补料分批培养中使用PLS进行过程监控和质量变量预测
3. Minimization of Glycerol Production during the High-Performance Fed-Batch Ethanolic Fermentation Process in Saccharomyces cerevisiae, Using a Metabolic Model as a Prediction Tool [J] . Carine Bideaux, Sandrine Alfenore, Xavier Cameleyre, Applied and Environmental Microbiology . 2006,第3期

机译：使用代谢模型作为预测工具，在酿酒酵母高效补料分批乙醇发酵过程中甘油的产生最小化
4. Quality Prediction for a Fed-Batch Fermentation Process Using Multi-Block PLS [C] . Jeong Jin Hong, Jie Zhang EU-Korea Conference on Science and Technology . 2010

机译：使用多块PLS对FED批量发酵过程的质量预测
5. Use of FT-IR/ATR sensors for online process control: Approximate solutions to the fed-batch fermentation control problem and the calibration/prediction problem with errors in the independent variables. [D] . Alberti, John C. 1990

机译：使用FT-IR / ATR传感器进行在线过程控制：分批补料发酵控制问题和标定/预测问题的近似解决方案，其中自变量存在误差。
6. Minimization of Glycerol Production during the High-Performance Fed-Batch Ethanolic Fermentation Process in Saccharomyces cerevisiae Using a Metabolic Model as a Prediction Tool [O] . Carine Bideaux, Sandrine Alfenore, Xavier Cameleyre, 2006

机译：使用代谢模型作为预测工具在酿酒酵母高效补料分批乙醇发酵过程中甘油的产生最小化
7. Minimization of Glycerol Production during the High-Performance Fed-Batch Ethanolic Fermentation Process in Saccharomyces cerevisiae, Using a Metabolic Model as a Prediction Tool† [O] . Bideaux, Carine, Alfenore, Sandrine, Cameleyre, Xavier, 2006

机译：使用新陈代谢模型作为预测工具，在酿酒酵母高效补料分批乙醇发酵过程中将甘油产量降至最低
8. Application of Multi-Block, Patched Grid Topologies to Navier-Stokes Predictions of the Aerodynamics of Army Shell [R] . Haroldsen, D. J. , Sturek, W. B. 2001

机译：多块补丁网格拓扑在陆军空气动力学Navier-stokes预测中的应用

Quality Prediction for a Fed-Batch Fermentation Process Using Multi-Block PLS

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