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Availability of thiazone as an enhancer for optical clearing of skin tissue in vitro

机译：噻onone作为用于光学清除皮肤组织的增强剂的供应性

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Dimethyl sulfoxside(DMSO) has been used as enhancer for tissue optical clearing technique. However, due to its potential toxicity and possible side effects, taking clearing effects and clinical availability into accounts, a new enhancer will be needed in order to facilitate practical application of tissue optical clearing technique to non-invasive light-based diagnostic and imaging technique. In this talk, it is our aim to introduce a new skin penetration promoter, thiazone, used in the fields of pharmaceutic industry, cosmetic, etc and investigate its availability as a new enhancer for tissue optical clearing technique. Firstly, we analyzed its structure, physical and chemical properties. And then we performed experimental investigation of the effect of DMSO and thiazone as enhancers mixed with polyethylene glycol (PEG) respectively on optical clearing of porcine skin tissue in vitro. Results of direct observation from camera reveal that thiazone has a higher penetration enhancing effect when compared with DMSO as an enhancer when porcine skin was topically impregnated by different mixed-solutions. Optical property parameters, obtained by using double integrating-spheres system and Inverse Adding-Doubling (IAD) method, showed that thiazone led to almost similar reduction in scattering to DMSO did during the same time period. Therefore, in terms of optical application and clinical safety, thiazone could be a better choice than DMSO as an enhancer for optical clearing of skin tissue.
机译：二甲基磺砜（DMSO）已被用作组织光学清除技术的增强子。然而，由于其潜在的毒性和可能的​​副作用，将清除效果和临床可用性进入账户，需要一种新的增强剂，以便于实际应用组织光学清除技术对非侵入式基于光的诊断和成像技术。在这次谈判中，我们的目标是引入新的皮肤渗透推动子，噻onone，用于药用工业，化妆品等领域，并调查其作为组织光学清除技术的新增强剂的可用性。首先，我们分析了其结构，物理和化学性质。然后我们对猪皮肤组织的光学清除进行了与聚乙二醇（PEG）混合的增强剂，对DMSO和噻唑酮的影响进行了实验研究。相机直接观察结果显示，当猪皮被不同的混合溶液局部浸渍时，与DMSO相比，噻唑的渗透性增强效果更高。光学特性参数，通过使用双积极球系统和反向添加加倍（IAD）方法获得的，显示噻唑导致在同一时间段内对DMSO的散射几乎相似。因此，在光学应用和临床安全方面，噻唑酮可以是比DMSO更好的选择，作为皮肤组织的光学清除的增强剂。

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