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Biological Allofibroblast-based Dressing Decreases the Duration of Superficial Burn Healing

机译：基于生物的Allofrobrobrast基敷料降低了表面灼伤愈合的持续时间

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According to the Moscow Burn Centre data, two thirds of 800-900 annually admitted patients have the II degree burns (partial thickness burns), involving more than 20% TBS A in one third of them. It is known that the spontaneous healing of the II degree burns takes 20-22 days and proceeds mainly by hypertrophic scar formation. Epidermis regeneration is achieved due to the activation, migration, and proliferation of keratinocytes both from surrounding epidermis (marginal epithelialization), and from the skin appendages (focal epithelialization) [3]. Burn wound dermal matrix denaturated by the heat exposure does not provide a directed motion of the keratinocytes to the affected zone. Reconstruction of the derma collagen net is ensured by firbroblasts, their necessary concentration in the affected zone being achieved slowly [1]. Previously it was shown that the fibroblast grafting significantly increased the epithelialization of the burn wound; however, the results of different studies vary depending on the methods and timing of fibroblast applications.
机译：根据莫斯科烧伤中心数据，800-900每年入院病人三分之二具有II度烧伤（部分厚度烧伤），在其中三分之一涉及超过20％TBS甲。已知的是，所述II度烧伤的愈合自发需要20-22天，并主要由前进肥厚性瘢痕形成。表皮再生是由于活化，迁移和角质形成细胞增殖的影响既从周围表皮（边际上皮），并从皮肤附属物（焦点上皮形成）[3]来实现的。烧伤创面真皮基质变性由热暴露不提供角化细胞到受影响的区域中的定向运动。真皮胶原净的重建通过firbroblasts确保，慢慢地被实现在受影响的区域其必要浓度[1]。先前已表明成纤维细胞显著接枝增加了烧伤伤口的上皮形成;然而，不同的研究的结果取决于方法和成纤维细胞的应用定时。

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