DOMAIN COMPLEXITY OF PLANT KINESINS

机译：植物Kinesins的域复杂性

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The Arabidopsis genome contains 61 kinesins, the largest kinesin family of any fully sequenced and annotated genome. Characterizing each member of a large protein family is a difficult and laborious task, not only due to the size, but also the inherent diversification and/or redundancy associated with gene duplication. An alternative approach to better understand the Arabidopsis kinesin family is to study the domain composition of these proteins. Domains are defined as the structural and functional units of proteins. Understanding the domains and domain structure of an unknown protein often allows for a reliable prediction of function when experimental evidence is unavailable. Kinesins share a highly conserved motor domain with low sequence similarity outside of this domain, and many members contain additional protein domains in the nonconserved regions. New arrangements of domains, by means of genetic duplication, replication, or loss, result in novel proteins with unique functions. Using both the Arabidopsis and other sequenced genomes, it was found that several kinesins have protein domain arrangements specific to different lineages, providing compelling evidence for the evolution of kinesins with novel functions. A phylogenic analysis of plant-specific kinesin domains, as well as a comparative review of the molecular/ biochemical functions of these domains, is presented in this chapter. Combined, they provide an alternative means to understanding and developing more direct and relevant hypotheses concerning novel kinesins.

机译：拟南芥基因组包含61个驱动蛋白，最大的驱动蛋白家族任何完全测序和基因组注释的。表征大蛋白家族的每个成员是一个困难和费力的任务，这不仅是由于尺寸，而且固有的多样化和/或冗余与基因复制相关联。另一种方法，以便更好地了解拟南芥驱动蛋白家族是研究这些蛋白质的域组成。域被定义为蛋白质的结构和功能单元。理解的未知蛋白的结构域和结构域结构常常允许的功能的可靠的预测时的实验证据是不可用的。驱动蛋白共享与此域的低的序列相似性之外的高度保守的运动结构域，和许多成员包含在非保守区域附加的蛋白质结构域。域的新安排，通过基因复制，复制，或损失的手段，导致具有独特的功能的新的蛋白质。同时使用拟南芥和其他测序的基因组，发现几个驱动蛋白具有蛋白质结构域安排具体到不同谱系，对于新功能的驱动蛋白的进化提供了令人信服的证据。植物特异性驱动蛋白结构域的种系发生的分析，以及对这些结构域的分子/生物化学功能比较审查，提出本章英寸相结合，他们提供了一个替代手段，以理解和发展有关的新驱动蛋白更直接相关的假说。

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《NATO Advanced Research Workshop on The Plant Cytoskeleton》|2008年||共22页
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中图分类生物工程学（生物技术）;
关键词
kinesins; plant genomes; protein domains;

机译：Kinesins;植物基因组;蛋白质领域;

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专利

1. Half-Site Inhibition of Dimeric Kinesin Head Domains by Monomeric Tail Domains [J] . David D. Hackney Nahyeon Baek and Avin C. Snyder Biochemistry . 2009,第15期

机译：单体尾结构域对二聚体驱动蛋白头部结构域的半位抑制
2. Photo-control of kinesin-microtubule motility using caged peptides derived from the kinesin C-terminus domain [J] . Nomura A, Uyeda TQP, Yumoto N, Chemical Communications . 2006,第34期

机译：使用衍生自驱动蛋白C末端域的笼状肽对驱动蛋白微管运动进行光控制
3. The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain [J] . Diefenbach RJ., Armati PJ., Cunningham AL., Biochemistry . 1998,第47期

机译：普遍存在的人驱动蛋白重链的茎结构域的C末端区域包含驱动蛋白轻链的结合位点
4. DOMAIN COMPLEXITY OF PLANT KINESINS [C] . NATO Advanced Research Workshop on The Plant Cytoskeleton . 2008

机译：植物Kinesins的域复杂性
5. Understanding novel protein function from protein domains in the plant kinesin superfamily. [D] . Malcos, Jennelle L. 2009

机译：从植物驱动蛋白超家族的蛋白质结构域中了解新型蛋白质功能。
6. Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like ankyrin repeats and PH domains 1 (AGAP1). [O] . Ruibai Luo, Pei-Wen Chen, Michael Wagenbach, 2016

机译：驱动蛋白13家族成员驱动蛋白样蛋白2A（Kif2A）和Arf GAP与GTP结合蛋白样蛋白锚蛋白重复序列和PH结构域1（AGAP1）的直接功能相互作用。
7. The calmodulin-binding domain from a plant kinesin functions as a modular domain in conferring Ca 2� -calmodulin regulation to animal plus- and minus-end kinesins [O] . Vaka S. Reddy, Anireddy S. N. Reddy 2002

机译：来自植物驱动蛋白的钙调蛋白结合结构域作为模块结构域起作用，赋予动物正端和负端驱动蛋白Ca 2+ - 钙调蛋白调节。

DOMAIN COMPLEXITY OF PLANT KINESINS

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