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Bioinformatics Analyses of Deinococcus radiodurans in order to Waste clean up

机译：生物信息学分析Deinococcus radiodurans，以浪费清理

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Environmental pollutants have become a major global concern. The waste generated from the development of products and processes are of concern to the environmentalist. One of the major issues in recent times is the threat to the human life caused due to the progressive deterioration of the environment. The waste generated from the development of products and processes are of concern to the environmentalist. Heavy metals are also reported persisting into the environment causing toxicity to living organisms through bioaccumulation, adsorption and biotransformation. A number of microorganisms, as a result of their versatility adaptability and diversity in the environment, are considered to be the best candidates among all living organisms to remediate most of the environmental contaminants into the natural biogeochemical cycle. These natural forces of biodegradation can reduce waste and cleanup some types of environmental contaminants. Compositing can accelerate natural biodegradation and convert organic wastes to valuable resources. Deinococcus radiodurans is known as the world's toughest bacteria and it is the most radiation resistant organism known. Scientists are interested in this organism because of its potential usefulness in cleaning up waste sites that contain radiation and toxic chemicals. It can tolerate radiation levels at 1000 times the levels that would kill a human and it was originally isolated in 1956 from a can of meat that had been irradiated with X-rays. The bacterium can tolerate high levels of chemical, oxidative, UV, and ionizing radiation-induced damage to the cell's DNA, which it efficiently repairs. The resistance to radiation may reflect its resistance to dessication, which also causes DNA damage. This organism may be of use in cleaning up toxic metals found at nuclear weapons production sites due to the radiation resistance. Deinococcus has been genetically engineered for use in bioremediation to consume and digest solvents and heavy metals, even in a highly radioactive site. For example, the bacterial mercuric reductase gene has been cloned from Escherichia coli into Deinococcus to detoxify the ionic mercury residue frequently found in radioactive waste generated from nuclear weapons manufacture. This bacterium is also a highly efficient transformer, and can readily take up exogenous DNA from the environment, which may also aid DNA repair. Bioinformatics offers many interesting possibilities for bioremediation from environment protection point of view, genomic and bioinformatic data provide a wealth of information that would be greatly enhanced by structural characterisation of some of these proteins in them. It can be extended to follow the leads provided by collaborating bioinformatics experts and proteomics studies. This may ultimately result not only in a more complete understanding of the radiation resistance of this bacterium, but also to the discovery of novel DNA repair systems, applicable to an understanding of the mechanisms of higher organisms such as man. Analysis of paralogs in Deinococcus has revealed several unique protein families. In addition, specific expansions of several other families including phosphatases, proteases, acyltransferases, and Nudix family pyrophosphohydrolases were detected. Genes that potentially affect DNA repair and stress responses and recombination were investigated in this article. these observations suggest that several different biological mechanisms contribute to the multiple DNA repair-dependent phenotypes of this organism. Then D.radiodurans as a bioremediation agent, can remove heavy metals and organic solvents such that the subsequent radionuclide isolation is safer and easier. This analysis is a single substantiation of function of Nudix protein family with is taken from D.radiodurans R1, for the purpose of waste clean up.
机译：环境污染物已成为全球主要关注点。从产品和过程的开发产生的废物是环保主义者的关注。最近的一个主要问题之一是由于环境逐步恶化，对人类生命的威胁。从产品和过程的开发产生的废物是环保主义者的关注。据报道，重金属也持续到通过生物累积，吸附和生物转化导致生物体的毒性引起毒性。由于它们在环境中的功能性和多样性的结果，许多微生物被认为是所有生物体中最好的候选人，以将大部分环境污染物妥善处理到天然生物地球化学循环中。这些生物降解的自然力量可以减少浪费并清理某些类型的环境污染物。合成可以加速天然生物降解，并将有机废物转化为宝贵的资源。 Deinococcus radiodurans被称为世界上最艰难的细菌，它是已知的最抗抗抗性生物。科学家们对这种有益于这种有用性，因为它在清理含有辐射和有毒化学物质的废物位点。它可以耐受辐射水平在1000倍的水平，这些水平将杀死人类，它最初于1956年从一罐用X射线照射的肉中孤立。细菌可以耐受高水平的化学，氧化，紫外线和电离辐射诱导对细胞的DNA损伤，其可有效地修理。抗辐射的抗性可能反映其对DESS的抗性，这也导致DNA损伤。这种有机体可以用于清洁由于辐射抗性而在核武器生产地点发现的有毒金属。耐候在遗传设计中用于生物修复，即使在高放射性位点也消耗和消化溶剂和重金属。例如，细菌汞还原酶基因已从大肠杆菌中克隆到Deinococcus中，以解毒来自核武器制造产生的放射性废物中经常发现的离子汞残留物。该细菌也是一种高效的变压器，并且可以容易地从环境中占用外源性DNA，这也可能有助于DNA修复。生物信息学提供了来自环境保护的生物修复的许多有趣的可能性，基因组和生物信息数据提供了丰富的信息，这些信息将通过它们中的一些蛋白质的结构表征而大大提高。它可以扩展到遵循通过协作生物信息学专家和蛋白质组学研究提供的领导。这可能最终不仅在更完全了解对该细菌的辐射抗性，而且还可以对新型DNA修复系统的发现，适用于理解男人如男人的较高生物的机制。耐肺炎病虫病分析揭示了几个独特的蛋白质。此外，检测到包括磷酸酶，蛋白酶，酰基转移酶和Nudix家族焦磷酸酶的几个其他家族的特定膨胀。在本文中研究了可能影响DNA修复和应激反应和重组的基因。这些观察结果表明，几种不同的生物学机制有助于这种生物体的多种DNA修复依赖性表型。然后D.Radiodurans作为生物修复剂，可以去除重金属和有机溶剂，使得随后的放射性核素隔离更安全，更容易。该分析是Nudix蛋白质家族的单一证实，从D.Radiodurans R1中取出，以便废物清理。

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