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首页> 外文会议>European Congress of Immunology >NK cells, T-Iymphocyte subsets, and serum cytoklnes six months after autologous hematopoietic stem cell transplantation
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NK cells, T-Iymphocyte subsets, and serum cytoklnes six months after autologous hematopoietic stem cell transplantation

机译：NK细胞，T-inymphyte子集和自体造血干细胞移植后六个月六个月血清Cytoklnes

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We investigated peripheral blood lymphocyte subsets and Thl/Th2 cytokine serum levels before and in the course of six months following successful autologous hematopoietic stem cell transplantation (aHSCT). The highly cytotoxic CD 160+ NK subset progressively recovered from M2 to M6. Reconstituted T cells comprised mostly effector memory (EM) and effector (E) CD8+ subsets, and CD4+ T were antigen-experienced Th1-like central-memory (CM) cells. While IL-10 levels before aHSCT were either too low (mean 3.8 pg/ml) or too high (mean 10.5 pg/ml), (MW p< 0.001), they were modulated within the reference interval (3-11 pg/ml) at M6. Moreover, IL-10 concentrations at M2 and M6 correlated positively with IFN-gamma (R=0.36), the proportion and absolute count (AC) of NK cells (R=0.4), and - negatively with the proportion of activated (CD57+CD28+) CD8 T cells (R= - 0.76). Thus, IL-10 may regulate post-aHSCT reconstitution by modulating Th1 immune responses, and eventual GVHD-like effects.
机译：在成功的自体造血干细胞移植（AHSCT）后，我们在六个月之前和六个月内研究了外周血淋巴细胞亚群和THL / TH2细胞内血清水平。高细胞毒性CD 160+ NK子集从M2逐渐回收到M6。重构的T细胞包含主要效应存储器（EM）和效应（E）CD8 +亚群，CD4 + T是抗原经历的TH1样中央存储器（CM）细胞。虽然AHSCT之前的IL-10水平过低（平均3.8pg / ml）或过高（平均10.5 pg / ml），但它们在参考间隔内调制它们（3-11 pg / ml ）在M6。此外，在M2和M6的IL-10浓度与IFN-γ（R = 0.36）相关，NK细胞的比例和绝对计数（r = 0.4），以及 - 与活化的比例负 - 呈否定（CD57 + CD28 +）CD8 T细胞（R = - 0.76）。因此，IL-10可以通过调节Th1免疫应答，并且最终的GVHD样效果来调节AHSCT后重构。

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