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首页> 外文会议>European Congress of Immunology >Passive Blood Anaphylaxis: Substandard immunoglobulins are a source of passive anaphylactic reaction
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Passive Blood Anaphylaxis: Substandard immunoglobulins are a source of passive anaphylactic reaction

机译：被动血对不合标准的免疫球蛋白是被动过敏反应的源

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A serious allergic reaction (local and generalized) after subcutaneous infusion of immunoglobulin was described in this report. A 46-year-old woman with common variable immunodeficiency was qualified to immunoglobulin replacement therapy. Unexpectedly oedema, confluent wheals and erythema in the place of subcutaneous immunoglobulin infusion(ScIg) were observed. Early and late phase of reaction occured (20 min and 6-12 h after infusion). Serum regain level was undetectable before and after ScIg infusion (18 IU/ml). So we tested the IgE concentration in a series of drug samples. It was between 138 and 232IU/ml. Specific IgE (UNICAP 100 PHARMACIA) was within the wide range from 198 (mix of food) to 2809 KUA/l (mix of grass), but many of the tested allergen-specific IgE were class 2 or 3 (i.e. 0,71-17,5 KUA/1). Furthermore, allergic rhinoconjunctivitis and acute urticaria developed later, after allergen exposure (when she went to the country). The case resembles classical passive cutaneous anaphylaxis and Prausnitz-Kiistner (PK) reaction. This observation indicates that anaphylactic reactions during immunoglobulin replacement therapy may result from IgE impurity of the substandard commercial immunoglobulin product. This report emphasizes that subcutaneous immunoglobulin administration as an option to treat patients at home is controversial.
机译：在本报告中描述了一种严重的过敏反应（局部和广义）在本报告中描述了免疫球蛋白。一名共同可变免疫缺陷的46岁女性符合免疫球蛋白替代疗法。在皮下免疫球蛋白输注（SCIG）的情况下，意外的水肿，融合的圆形和红斑。早期和后期反应的阶段发生（输注后20分钟和6-12小时）。在突出的输注之前和之后，血清重新获得水平未检测到（18 iu / ml）。因此，我们在一系列药物样品中测试了IgE浓度。它在138到232iu / ml之间。特异性IgE（UNICAP 100 Pharmacia）在198（食物混合）至2809kua / L（草混合）范围内，但许多测试过敏原特异性IgE是2或3类（即0,71- 17,5 Kua / 1）。此外，过敏原暴露后后来发育过敏性鼻咽炎和急性荨麻疹（当她去国内时）。这种情况类似于古典被动皮肤过敏性和Prausnitz-kiistner（PK）反应。该观察结果表明，免疫球蛋白替代治疗期间的过敏反应可能是由IgE的IgEncoglobloblobloblobloblin产物的IgE杂质产生。本报告强调皮下免疫球蛋白给药作为治疗家庭治疗患者的选择是有争议的。

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