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首页> 外文会议>International Conference on Environmental, Industrial and Applied Microbiology >Streptococcus intermedius trigger quorum-sensing genes in Porphyromonas gingivalis
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Streptococcus intermedius trigger quorum-sensing genes in Porphyromonas gingivalis

机译：中霉菌菌触发卟啉核糖菌的触发批量传感基因

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Quorum sensing is a genetic regulation in response to cell density that can regulates various functions in bacteria. Among them we can find various cell functions associated with secondary metabolism, biofilm formation and virulence gene expression. This phenomenon was discovered in the marine bacteria Vibrio fischeri and Vibrio harveyi who produce autoinducers, and when their concentration reaches a threshold level in environment, they bind to a response regulator protein and induce expression of luciferase gene cluster. Today, we can recognized two kind of quorum-sensing systems in V. harveyi, one utilizes an acylhomoserine lactone as the signal and other uses a luxS-encoded signal. Porphyromonas gingivalis is an oral bacterium that has been implicated in periodontitis, and it possesses a luxS gene homologue that might be implicated not only in a quorum-sensing system but also in stress gene regulation. In this study, we report the regulation of gene expression in P. gingivalis as response to different cell concentration of Streptococcus intermedius, another natural oral habitant. Both bacteria were incubated at next ratios: 1:1, 1:10 and 10:1 of P. gingivalis: S. intermedius. The genetic expression of the locus PG0520, PG0538 and PG1280 was evaluated with qPCR.
机译：致法感测是响应细胞密度的遗传调节，可调节细菌中的各种功能。其中我们可以找到与次生新陈代谢，生物膜形成和毒力基因表达相关的各种细胞功能。这种现象在海洋细菌vibrio fischeri和vibrio harveyi中发现了生产血管造影，并且当它们的浓度达到环境中的阈值水平时，它们与响应调节蛋白结合并诱导荧光素酶基因簇的表达。如今，我们可以在V.Arveyi中认识到两种仲裁传感系统，其中一个人使用酰基骨晶内酯作为信号等，使用LUX编码信号。 Porphyromonas Gingivalis是一种口腔细菌，它涉及牙周炎，它具有Luxs基因同源物，其不仅可以涉及到批量传感系统，也可能涉及应激基因调节。在这项研究中，我们报告了牙龈牙龈基因表达的调节，作为对中间体中素不同细胞浓度的反应，另一种天然口腔习性。两种细菌在下一个比率孵育：1：1，1:10和10：1的P.Gingivalis：S.中间型。用QPCR评估基因座PG0520，PG0538和PG1280的遗传表达。

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