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首页> 外文会议>International Conference on Environmental, Industrial and Applied Microbiology >Syzygium aromaticum (clove) extract reduce virulence factors mediated by QS in Gram negative bacteria
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Syzygium aromaticum (clove) extract reduce virulence factors mediated by QS in Gram negative bacteria

机译：Syzygium aromaticum（丁香）提取物减少QS介导的毒力因子在革兰氏阴性细菌中

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摘要

The process common to several diseases produced by Gram negative bacteria, now is known that are related to the cell density, mediated by the regulation of gene expression. This process is called autoinduction or 'quorum sensing' (QS). QS is regulate by a variety of different molecules used as signals for gene expression activation or inhibition. Eighteen methanolic extracts from herbs and spices were tested to determinate their ability to inhibit QS in Chromobacterium violaceum, Salmonella Thyphimurium and Pseudomonas aeruginosa PAO-1. Inhibition of violacein production in C. violaceum, Salmonella invasivity in HT-29 cells, and swarming motility and alginate production in P. aeruginosa were tested. Only Syzygium aromaticum (clove) extract reduced AHL and violacein production from C. violaceum, Salmonella invasivity, and alginate synthesis and swarming motility in P. aeruginosa.
机译：现在已知由革兰氏阴性细菌产生的几种疾病的方法，其与基因表达的调节介导的细胞密度有关。此过程称为自动化或“Quorum感应”（QS）。 Qs通过用作基因表达活化或抑制的信号的各种不同的分子调节。测试了来自草药和香料的18个甲醇醇，以确定其在紫杉杆菌，沙门氏菌噻菌和假单胞菌铜绿假单胞菌Pao-1中抑制QS的能力。在C. ur-29细胞中抑制violacein产量，HT-29细胞中的沙门氏菌侵入性以及P.铜绿假单胞菌中的蜂拥而至的运动和藻酸盐产生。只有Syzygium aromaticum（Clove）提取物从C. violaceum，沙门氏菌侵入性和藻酸盐合成和藻酸盐合成和繁殖的动力中减少了Ahl和vioracein生产。

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