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首页> 外文会议>Neurosciences and Music Conference >Evidence for Plasticity in White-Matter Tracts of Patients with Chronic Broca's Aphasia Undergoing Intense Intonation-based Speech Therapy
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Evidence for Plasticity in White-Matter Tracts of Patients with Chronic Broca's Aphasia Undergoing Intense Intonation-based Speech Therapy

机译：慢性古典慢性古代血管性腺患者白品患者的可塑性证据

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Recovery from aphasia can be achieved through recruitment of either perilesional brain regions in the affected hemisphere or homologous language regions in the nonlesional hemisphere. For patients with large left-hemisphere lesions, recovery through the right hemisphere may be the only possible path. The right-hemisphere regions most likely to play a role in this recovery process are the superior temporal lobe (important for auditory feedback control), premotor regions/posterior inferior frontal gyrus (important for planning and sequencing of motor actions and for auditory-motor mapping), and the primary motor cortex (important for execution of vocal motor actions). These regions are connected reciprocally via a major fiber tract called the arcuate fasciculus (AF), however, this tract is not as well developed in the right hemisphere as it is in the dominant left. We tested whether an intonation-based speech therapy (i.e., melodic intonation therapy [MITI), which is typically administered in an intense fashion with 75-80 daily therapy sessions, would lead to changes in white-matter tracts, particularly the AE Using diffusion tensor imaging (DTI), we found a significant increase in the number of AF fibers and AF volume comparing post- with pretreatment assessments in six patients that could not be attributed to scan-to-scan variability. This suggests that intense, long-term MIT leads to remodeling of the right AF and may provide an explanation for the sustained therapy effects that were seen in these six patients.
机译：通过在非含有半球的受影响的半球或同源语言地区招募患者的血管性脑区，可以实现失语症的恢复。对于大左半球病变的患者，通过右半球恢复可能是唯一可能的路径。最有可能在该恢复过程中发挥作用的右半球区域是优越的时间叶（对听觉反馈控制的重要性），热球区/后级额相回值（对于电动机动作的规划和排序重要，以及听觉电机映射很重要）和主电机皮质（用于执行声音电机动作的重要）。这些区域通过称为弧形筋膜（AF）的主要纤维束相互连接，然而，这种道路在右半球中也不产生，因为它在左侧的主导地位。我们测试了是否基于语调的语音疗法（即旋律语调治疗[Miti），其通常以浓度的方式施用75-80个日常治疗疗程，将导致白物理束的变化，特别是使用扩散的AE张量成像（DTI），我们发现AF纤维和AF体积的数量显着增加，比较六名患者的预处理评估，这些患者不能归因于扫描到扫描变异性。这表明强烈，长期麻省理工学院导致重塑自动对焦，并且可以对这六名患者中所见的持续治疗效果提供解释。

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