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Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism

机译：自闭症般的完全非语言儿童的弓形筋膜筋膜的非典型半球不对称

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Despite the fact that as many as 25% of the children diagnosed with autism spectrum disorders are nonverbal, surprisingly little research has been conducted on this population. In particular, the mechanisms that underlie their absence of speech remain unknown. Using diffusion tensor imaging, we compared the structure of a language-related white matter tract (the arcuate fasciculus, AF) in five completely nonverbal children with autism to that of typically developing children. We found that, as a group, the nonverbal children did not show the expected left-right AF asymmetry-rather, four of the five nonverbal children actually showed the reversed pattern. It is possible that this unusual pattern of asymmetry may underlie some of the severe language deficits commonly found in autism, particularly in children whose speech fails to develop. Furthermore, novel interventions (such as auditory-motor mapping training) designed to engage brain regions that are connected via the AF may have important clinical potential for facilitating expressive language in nonverbal children with autism.
机译：尽管有多达25％的儿童诊断出患有自闭症谱系障碍是非言喻的，但令人惊讶地对这群人口进行了令人惊讶的几乎没有研究。特别是，他们没有言论的机制仍然是未知的。使用扩散张量成像，我们将与初始非语言儿童的语言相关的白质子（弓形筋膜，AF）的结构进行了比较到典型的育种儿童。我们发现，作为一个团体，非语言儿童没有显示预期的左右AF不对称 - 而是五个非语言儿童中的四个实际上显示了逆转模式。这种不对称的这种不态的模式可能提出了自闭症中常见的一些严重语言缺陷，特别是在语言未能发展的儿童中。此外，设计用于接合通过AF连接的脑区域的新的干预（例如听觉电动机映射训练）可能具有重要的临床潜力，以促进自闭症非语言儿童中的表现语言。

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