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首页> 外文会议>Conference on endoscopic microscopy >Affinity Fluorescence-Labeled Peptides for the Early Detection ofCancer in Barrett's Esophagus
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Affinity Fluorescence-Labeled Peptides for the Early Detection ofCancer in Barrett's Esophagus

机译：亲和荧光标记的肽，用于早期检测Barrett食管中的癌症

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Fluorescence-labeled peptides that affinity bind to neoplastic mucsosa are promising for use as a specific contrast agentin the detection of pre-malignant tissue in the esophagus. This method is can be used to identify expression of biologicalmarkers associated with dysplasia on endoscopic imaging as a guide for biopsy and represents a novel method for theearly detection and prevention of cancer. We demonstrate the use of phage display to select affinity peptides andidentify the sequence "ASYNYDA" that binds with high target-to-background ratio to dysplastic esophageal mucosacompared to that of intestinal metaplasia. Validation of preferential binding is demonstrated for neoplasia in the settingof Barrett's esophagus. An optimal tradeoff between sensitivity and specificity of 82% and 85% was found at therelative threshold of 0.60 with a target-to-background ratio of 1.81 and an area under the ROC curve of 0.87. Peptides are anovel class of ligand for targeted detection of pre-malignant mucosa for purposes of screening and surveillance.
机译：荧光标记的肽的亲和性结合至肿瘤mucsosa是有希望用作特异性造影agentin在食道检测癌前组织。这种方法可以用于鉴定具有发育不良上内窥镜成像作为活检引导相关联的biologicalmarkers表达并代表theearly检测和预防癌症的新方法。我们展示了使用噬菌体展示来选择亲和力的肽andidentify序列“ASYNYDA”以高靶 - 背景比结合于食管发育异常mucosacompared到肠化生。优惠的验证证明在肿瘤settingof Barrett食管结合。灵敏度和82％和85％的特异性之间的最佳折衷在0.60与1.81的0.87的ROC曲线下的靶 - 背景比和面积therelative阈被发现。肽是一种新颖类配体癌前病变黏膜有针对性的检测的筛选和监控的目的。

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