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首页> 外文会议>International Symposium on Therapeutic Ultrasound (2002- ) >The Use of Susceptibility-Weighted Magnetic Resonance Imaging to Characterize the Safety Window of Focused Ultrasound Exposure for Localized Blood-Brain-Barrier Disruption
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The Use of Susceptibility-Weighted Magnetic Resonance Imaging to Characterize the Safety Window of Focused Ultrasound Exposure for Localized Blood-Brain-Barrier Disruption

机译：使用易感加权磁共振成像，以局部血型脑屏障中断的聚焦超声暴露的安全窗征

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High-intensity focused ultrasound has been discovered to be able to locally and reversibly increase the permeability of the blood-brain barrier (BBB), which can be detected using magnetic resonance imaging (MRI). However, side effects such as microhemorrhage, erythrocyte extravasations, or even extensive hemorrhage can also occur. Although current contrast-enhanced T1-weighted MRI can be used to detect the changes in BBB permeability, its efficacy in detecting tissue hemorrhage after focused-ultrasound sonication remains limited. The purpose of this study was to determine the feasibility of using MR susceptibility-weighted imaging (SWI) to identify tissue hemorrhage associated with the process of BBB permeability increase and characterize the safety window of acoustic pressure level. Brains of 42 Sprague-Dawley rats were subjected to 107 sonications either unilaterally or bilaterally. Contrast-enhanced T1-weighted images, together with SWI were performed. Tissue damage and hemorrhage were analyzed histologically with light microscopy and staining by Evan's blue, HE staining as well as TUNEL staining. Our results showed that contrast-enhanced T1 weighted imaging is sensitive to the presence of the BBB disrupture, but was unable to differentiate from extensive tissue damage such as hemorrhage. Also, SWI proved to be a superior tool for the realtime monitoring of the presence of hemorrhage, which is essential to the clinical concerns. The safety operation window in vivo in our study indicated a pressure of 0.78 to 1.1 MPa. to increase the BBB permeability successfully without hemorrhage. Potential applications such as drug delivery in the brain might be benefited.
机译：已经发现高强度聚焦超声波能够在局部和可逆地增加血脑屏障（BBB）的渗透率，其可以使用磁共振成像（MRI）来检测。然而，也可以发生副作用，例如微量血清，红细胞外渗，甚至广泛出血。虽然电流对比度增强的T1加权MRI可用于检测BBB渗透性的变化，但在聚焦超声超声处理后检测组织出血的功效仍然有限。本研究的目的是确定使用MR易敏感性加权成像（SWI）的可行性来鉴定与BBB渗透率的过程相关的组织出血，并表征声压水平的安全窗。 42 Sprague-Dawley大鼠的大脑无论是单侧还是双侧的107个超声。对比度增强的T1加权图像与SWI一起进行。通过光学显微镜分析组织损伤和出血，并通过Evan的蓝色染色，他染色以及Tunel染色。我们的结果表明，对比增强T1加权成像是对BBB disrupture的存在敏感，但无法从广泛组织损伤来区分如出血。此外，SWI被证明是实时监测出血存在的优越工具，这对临床关注至关重要。我们研究中的体内安全操作窗口表示为0.78至1.1 MPa的压力。在没有出血的情况下成功增加BBB渗透率。大脑中药物递送的潜在应用可能会受益。

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