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首页> 外文会议>International Symposium on Therapeutic Ultrasound (2002- ) >Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
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Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection

机译：超声透皮胰岛素递送对皮下胰岛素注射剂的剂量比较

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Prior studies have demonstrated the effectiveness of noninvasive transdermal insulin delivery using a cymbal transducer array. In this study the physiologic response to ultrasound mediated transdermal insulin delivery is compared to that of subcutaneously administered insulin. Anesthetized rats (350-550 g) were divided into four groups of four animals; one group representing ultrasound mediated insulin delivery and three representing subcutaneously administered insulin (0.15, 0.20, and 0.25 U/kg). The cymbal array was operated for 60 minutes at 20 kHz with 100 mW/cm2 spatial-peak temporal-peak intensity and a 20% duty cycle. The blood glucose level was determined at the beginning of the experiment and, following insulin administration, every 15 minutes for 90 minutes for both the ultrasound and injection groups. The change in blood glucose from baseline was compared between groups. When administered by subcutaneous injection at insulin doses of 0.15 and 0.20 U/kg, there was little change in the blood glucose levels over the 90 minute experiment. Following subcutaneous administration of insulin at a dose of 0.25 U/kg, blood glucose decreased by 190 +- 96 mg/dl (mean +- SD) at 90 minutes. The change in blood glucose following ultrasound mediated insulin delivery was -262 +- 40 mg/dl at 90 minutes. As expected, the magnitude of change in blood glucose between the three injection groups was dependant on the dose of insulin administered. The change in blood glucose in the ultrasound group was greater than that observed in the injection groups suggesting that a higher effective dose of insulin was delivered.
机译：先前的研究表明使用钹换能器阵列的非侵入性透皮胰岛素递送的有效性。在这项研究中，将对超声介导的透皮胰岛素递送的生理学反应与皮下给药的胰岛素进行比较。将麻醉的大鼠（350-550g）分为四组四组;表示超声介导的胰岛素递送的一组，并且三个代表皮下给药的胰岛素（0.15,0.20和0.25u / kg）。在20kHz下操作钹阵列60分钟，具有100mW / cm2空间峰值时间峰值强度和20％的占空比。血糖水平在实验开始时测定，并且在胰岛素给药后，每15分钟持续90分钟，用于超声和注射组。在组之间比较了基线的血糖的变化。当通过皮下注射在胰岛素剂量的0.15和0.20 U / kg的给药，有在比90分钟实验的血糖水平变化不大。在0.25u / kg剂量的皮下施用胰岛素之后，血糖在90分钟内通过190±96mg / dl（平均±96mg / dl（平均±SD）降低。超声介导的胰岛素递送后血糖的变化为-262±40mg / dL，在90分钟。如预期的那样，三个注射组之间的血糖变化的程度依赖于施用胰岛素的剂量。超声组中血糖的变化比在注射组表明胰岛素的更高的有效剂量被输送观察到的大得多。

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