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首页> 外文会议>European Meeting on Glial Cells in Health and Disease >Cognitive status of patients after radiotherapy for nasopharyngeal carcinoma-a half year follow-up study
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Cognitive status of patients after radiotherapy for nasopharyngeal carcinoma-a half year follow-up study

机译：鼻咽癌放射治疗后患者的认知状态 - 半年的后续研究

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Objectives: To investigate sequential changes of cognitive function in nasopharyngeal carcinoma (NPC) patients at early-stage of post radiotherapy with neuropsychological and neurophysiological tests. Patients and methods: 72 pre-radiotherapy NPC patients and 36 ages-, gender- and education-matched controls were evaluated by a Chinese version of WAIS-R (WAIS-RC) and P300 auditory event-related potentials (P300). To follow up patients' WAIS-RC and P300 in 3rd day, 3rd month and 6th month after radiotherapy and carry out comparisons of patients' cognitive data and P300 values in all tests respectively. Results: The diffuse pattern of postradiation cognitive deficits showed in WAIS-RC evaluation. The longer follow-up, the more cognitive domains dyfunction involved. The time course of post radiotherapy was correlated with the severity of cognitive deficits in both WAIS-RC and P300 tests. Conclusion: Both WAIS-RC and P300 results demonstrated a relatively diffuse pattern of postradiation cognitive deficits characterized by persistent impairment in NPC patients during half-year follow-up.
机译：目的：探讨鼻咽癌早期鼻咽癌（NPC）患者的认知功能的顺序变化，具有神经心理学和神经生理学检验。患者和方法：72个放射治疗NPC患者和36岁的患者，通过中文版WAIS-R（WAIS-RC）和P300听觉事件相关潜力（P300）评估了性别和教育匹配的对照。在放疗后第3天，第3个月和第6个月内跟踪患者WAIS-RC和P300，并分别在所有测试中进行患者认知数据和P300值的比较。结果：WAIS-RC评估中Postradiation认知缺陷的漫反射模式显示。较长的随访，涉及的认知域名更多。后放射治疗的时间过程与WAIS-RC和P300测试中的认知缺陷的严重程度相关。结论：WAIS-RC和P300的结果表明，在半年随访期间，在NPC患者中持续损害的特征在于具有相对漫反射的Postradiation认知缺陷模式。

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