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首页> 外文会议>Triennial Meeting of the International Basal Ganglia Society >Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum
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Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum

机译：通过纹状体乙酰胆碱和尼古丁对多巴胺释放的调节是通过不同的烟碱乙酰胆碱受体在背侧与腹侧纹状体中

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摘要

Striatal dopamine (DA) neurotransmission plays a fundamental role in the reinforcing and ultimately addictive effects of nicotine. Both nicotine and endogenous acetylcholine (ACh) regulate Striatal DA release via P2 subunit-containing ((32*) nicotinicacetylcholine receptors (nAChRs) on Striatal axons. The subfamily of [32*-nAChRs responsible for these potent synaptic effects could offer a molecular target for therapeutic strategies in nicotine addiction. We explored the role of the a6p2*-nAChRs in the nucleus accumbens (NAc) and caudate-putamen (CPu) by observing action potential-dependent DA release from synapses in real time using fast-scan cyclic voltammetry at carbon-fibre micro-electrodes in mouse Striatal slices. We show that a6|32*-nAChRs dominate in the control of DA release by ACh and nicotine in NAc but have a more minor role in CPu alongside other p2*-nAChRs (e.g. a4*). These data offer new insights to suggest Striatal a6*-nAChRs as a molecular target for a therapeutic strategy for nicotine addiction.
机译：纹状体多巴胺（DA）神经递质在尼古丁的增强和最终上瘾的作用中起着重要作用。尼古丁和内源性乙酰胆碱（ACH）通过P2亚单位（（32×）烟酰基乙酰胆碱受体（NACHR）在纹状体轴突上调节纹状体DA释放。[32 * -NACHRS负责这些有效突触效应的亚家族可以提供分子靶标用于尼古丁成瘾的治疗策略。我们通过使用快速扫描循环伏安法实时观察来自突触的动作潜在依赖的DA释放A6P2 * -NACHRS在核常规（NAC）和尾部 - 腐蚀（CPU）中的作用在小鼠纹状体切片中的碳纤维微电极。我们表明A6 | 32 * -NACHRS在NAC中的ACH和尼古丁的控制中控制了DA释放，但在CPU和其他P2 * -NACHR中有更小的作用（例如， A4 *）。这些数据提供了新的见解，表明纹纹玻璃纹纹纹纹纹纹身A6 * -NACHR作为尼古丁成瘾治疗策略的分子靶标。

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