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首页> 外文会议>Annual World Conference on Carbon >RADIOSPECTROSCOPIC (EPR) AND QUANTUM CHEMICAL STUDY OF THE STRUCTURE OF COMPLEXES CARBON NANOTUBE-NITROXYL RADICAL
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RADIOSPECTROSCOPIC (EPR) AND QUANTUM CHEMICAL STUDY OF THE STRUCTURE OF COMPLEXES CARBON NANOTUBE-NITROXYL RADICAL

机译：辐射光谱（EPR）和量子化学研究络合物结构“碳纳米管 - 硝基根基”

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摘要

It is known that carbon nanotubes (CNT) can penetrate through cell membrane and into cytoplasm, thereby affecting the biochemical processes of subcellular organelles. Now this phenomenon is intensively investigated, so it is important for biology and medicine and until now remains practically opened. Method of spin probes with nitroxyl radical (NR) has been used for cytotoxicity research (integrity of erythrocytes membranes and mitochondrion activity) at molecular level [1, 2]. It was shown that the mechanism of CNT toxic action is caused by destruction of a cytoplasmatic membrane and inhibition of a respiratory chain of mitochondrial hepatocytes. However, it remains unclear question-if is it possible to identify the CNT labeled by paramagnetic probe and correspondingly could be used such CNT for studying kinetics and ways of their penetration in biological media.
机译：已知碳纳米管（CNT）可以穿透细胞膜和细胞质，从而影响亚细胞细胞器的生物化学过程。现在这种现象是集中调查的，因此对于生物学和药物来说是重要的，直到现在仍然实际开放。用硝基苯基自由基（NR）的旋转探针的方法已用于分子水平的细胞毒性研究（红细胞膜和线粒体活性的完整性）[1,2]。结果表明，CNT毒性作用的机制是由骨骺膜破坏引起的，并抑制线粒体肝细胞的呼吸链。然而，它仍然不清楚问题 - 如果可以识别由顺磁探针标记的CNT，并且相应地使用这种CNT用于研究动力学和它们在生物介质中的渗透方式。

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