Preparation of c-polylysine modified silica nanoparticles

机译：C-聚赖氨酸改性二氧化硅纳米粒子的制备

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Gene vector system is the key to realize gene transduction and therapy. A proper gene vector can introduce the target gene into cells securely, efficiently, controllably and easily, and achieve purposes of gene transfection and disease treatment after its expression. s-polylysine(s-PL), which is rich in cationic and has high penetrability through biological membrane,can be applied in DNA carrier. In this study, we presented a novel approach for preparing s-polylysine modified silica nanoparticles and combinating them with plasmid DNA.

机译：基因载体系统是实现基因转导和治疗的关键。适当的基因载体可以安全地，有效，可控地且容易地将靶基因引入细胞中，并达到其表达后基因转染和疾病治疗的目的。富含阳离子并通过生物膜具有高渗透性的S-聚硅烷（S-PL）可用于DNA载体。在该研究中，我们提出了一种制备S-聚赖氨酸改性二氧化硅纳米粒子并将它们与质粒DNA组合的新方法。

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《International Conference on Manufacturing Science and Engineering》|2013年||共4页
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作者
TAN Zhi-lei; Xing Bei; JiAShi-ru;
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原文格式 PDF
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中图分类 TB3-532;
关键词
α-polylysine; nanoparticle; gene carrier;

机译：α-聚赖氨酸;纳米粒子;基因载体;

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Preparation of c-polylysine modified silica nanoparticles

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