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首页> 外文会议>ICME International Conference on Complex Medical Engineering >Study of PNIPAAm-PEG thermo-sensitive copolymer micelle and application as drug carrier for icariin
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Study of PNIPAAm-PEG thermo-sensitive copolymer micelle and application as drug carrier for icariin

机译：乙基氨植物热敏共聚物胶束和应用作为icariin药物载体的研究

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A series of thermally responsive copolymers PNIPAAm-PEG were prepared through RAFT polymerization. Their molecular structures were verified by ~1H NMR spectroscopy and GPC. The temperature-dependent characteristics study has revealed that PNIPAAm-PEG exhibits a lower critical solution temperature (LCST) of about 34～42°C with the PNIPAAm:PEG molecular weight ratio of 1:1 to 10:1. When PNIPAAm:PEG=1.8:1, the polymer has a LCST of 37.8°C, which is very close to body temperature. The micelles also showed nearly 85% encapsulation efficiency for icariin with temperature dependent release. These results indicate that PNIPAAm-PEG is a promising drug carrier for icariin, and icariin- PNIPAAm-PEG has great potential in bone defect and disease treatment.
机译：通过筏聚合制备一系列热响应共聚物PNIPAAM-PEG。它们的分子结构通过〜1H NMR光谱和GPC验证。温度依赖性特征研究表明，PNIPAAM-PEG显示出约34〜42℃的低临界溶液温度（LCST），PNIPAAM：PEG分子量比为1：1至10：1。当PNIPAAM：PEG = 1.8：1时，聚合物的LCST为37.8℃，非常接近体温。胶束还显示出近85％的伊加霉素的封装效率，具有温度依赖性释放。这些结果表明，普哌甘蛋白是伊加里宁的有希望的药物载体，icariin-pnipaam-peg对骨缺损和疾病治疗具有很大的潜力。

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