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Reproducibility of Aortic Pulsatility Measurements From ECGGated Abdominal CTA in Patients with Abdominal Aortic Aneurysms

机译:腹主动脉瘤患者从腹部CTA再现脉动性测量的再现性

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Purpose: ECG-gated abdominal CT angiography with reconstruction of multiple, temporally overlapping CT angiography datasets has been proposed for measuring aortic pulsatility. The purpose of this work is to develop algorithms to segment the aorta from surrounding structures from CTA datasets across cardiac phases, calculate registered centerlines and measurements of regional aortic pulsatility in patients with AAA, and to assess the reproducibility of these measurements. Methods: ECG-gated CTA was performed with a temporal resolution of 165 ms, reconstructed to 1 mm slices ranging at 14 cardiac phase points. Data sets were obtained from 17 patients on which two such scans were performed 6 to 12 months apart. Automated segmentation, centerline generation, and registration of centerlines between phases was performed, followed by calculation of cross-sectional areas and regional and local pulsatility. Results: Pulsatility calculations for the supraceliac region were very reproducible between earlier and later scans of the same patient, with average differences less than 1% for pulsatility values ranging from 2% to 13%. Local radial pulsatilities were also reproducible to within -1%. Aneurysm volume changes between scans can also be quantified. Conclusion: Automated segmentation, centerline generation, and registration of temporally resolved CTA datasets permit measurements of regional changes in cross-sectional area over the course of the cardiac cycle (i.e., regional aortic pulsatility). These measurements are reproducible between scans 6-12 months apart, with differences in aortic areas reflecting both aneurysm remodeling and changes in blood pressure. Regional pulsatilities ranged from 2 to 13% but were reproducible at the 1% level.
机译:目的:ECG门控腹CT血管造影与重建多个,时间上重叠CT血管造影数据集已经用于测量主动脉脉动性。本作作品的目的是开发算法,以将主动脉从心脏阶段的CTA数据集进行周围结构进行分割,计算AAA患者的注册中心线和测量区域主动脉脉动性,并评估这些测量的再现性。方法:以165ms的时间分辨率进行ECG门控CTA,重建于1mm的切片,在14个心脏相位点。数据集是从17名患者获得,其中两种扫描分开6至12个月。进行自动分割,中心线生成和相位之间的中心线的登记,然后计算横截面积和区域和局部脉冲性。结果:同一患者的较早扫描之间的脉搏区域的脉动性计算非常可再现,平均差异小于2%至13%的脉动性值的1%。局部径向脉冲性也可重复于-1%。也可以量化扫描之间的动脉瘤音量变化。结论:自动分割,中心线生成和临时分解的CTA数据集的登记允许在心脏周期的过程中测量横截面积(即区域主动脉脉动性)的区域变化。这些测量在扫描的扫描中相隔6-12个月,主动脉区域的差异反映了动脉瘤重塑和血压变化。区域脉冲范围为2%至13%,但在1%水平上可重现。

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