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Interferon Correcting and Immunomodulating Therapy in Immunocompromized Patients with Viral Infections and Defects in Induced Intereferon Production

机译:免疫导航患者的干扰素校正和免疫调节治疗病毒感染患者和诱导诱导intreperens生产中的缺陷

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Clinical anamnestic peculiarities were studied, the system of interferons (IFN) and basic mechanisms of antiviral immunity in 142 patients with relapsing ARVI, recurrent herpes viral infections (HSV-1 and -HSV-2) infected with EBV, HHV6, CMV were tested. The defects of induced IFNα and IFNγ production, various disorders of basic mechanisms of antiviral immunity were revealed. The program of interferon and immune therapy was developed. It included replacement and interferon correcting, local and system, prolonged interferon therapy with recombinant IFNα - Viferon, correction of T cell link with Isoprinozin, correction of NK cells and neutrophil granulocyte (NG) with Likopid against the background of treatment scheme. Positive clinical immunologic effects, complete or partial restoration of induced IFNα and IFNγ production were registered in not less than 72.3% patients.
机译:研究了临床鞘内的特性,测试了干扰素系统(IFN)和抗病毒免疫的基本机制,在142名复发ARVI患者中,复发性疱疹病毒感染(HSV-1和-HSV-2)进行了eBV,HHV6,CMV。揭示了IFNα和IFNγ产生的缺陷,揭示了各种抗病毒免疫机制的疾病。制定了干扰素和免疫治疗程序。它包括替代和干扰素校正,局部和系统,具有重组IFNα - Viferon的延长的干扰素治疗,与IsOkinozin的T细胞连杆校正,NK细胞和中性粒细胞粒细胞(NG)与治疗方案的背景。患有IFNα和IFNγ产量的阳性临床免疫效应,完全或部分恢复在不低于72.3%的患者中。

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