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首页> 外文会议>SPIE Conference on Colloidal Quantum Dots for Biomedical Applications >Immobilization of Quantum Dots in Multiple Responsive Microgels forBiomedical Applications
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Immobilization of Quantum Dots in Multiple Responsive Microgels forBiomedical Applications

机译：多重响应微凝胶中的量子点固定化祛斑型应用

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A novel type of smart hybrid materials based on the in situ immobilization of quantum dots (QDs) on a responsive microgel template was prepared and investigated. Firstly, a temperature and pH dual responsive hybrid microgel was developed through the in-situ immobilization of CdS QDs in the interior of a copolymer microgel of poly(N-isopropylacrylamide-acrylamide-acrylic acid) [p(NIPAM-AAm-AA)]. The amino groups of the pAAm segments in the microgels are designed to sequester the precursor Cd~(2+) ions for in situ formation of CdS QDs in the interior of the microgels and stabilize the CdS QDs embedded in the microgels. We demonstrated that the carboxyl groups on the p(NIPAM-AAm-AA)-CdS hybrid microgels can be used for further coupling with 3-aminophenyl boronic acid for optical glucose sensing. The glucose concentration change can induce a reversible swelling/shrinkage of the hybrid microgels, which can further modify the physicochemical environment of the QDs immobilized inside the microgels, resulting in a reversible quenching/antiquenching in photoluminescence (PL). The method is extendable to other QDs with different emission wavelengths and other targeting ligands, thus it is possible to develop multifunctional hybrid micro-/nano-gels for additional important biomedical applications.
机译：一种新型的基于上一个响应微凝胶模板量子点（QD）的原位固定智能杂化材料的制备和调查。首先，温度和pH双重响应混合微凝胶是通过硫化镉QD的原位固定在聚（N-异丙基丙烯酰胺 - 丙烯酰胺 - 丙烯酸）[P（NIPAM-AAM-AA）]的共聚物微粒凝胶的内部开发。在微凝胶的聚丙烯酰胺部分的氨基被设计螯合前体镉〜（2+）离子在硫化镉量子点的原位形成在微凝胶的内部，并且稳定嵌入在微凝胶在CdS量子点。我们表明，在p（NIPAM-AAM-AA）中的羧基-CdS混合微凝胶可用于进一步耦合与3-氨基苯基硼酸用于光学葡萄糖感测。中的葡萄糖浓度的变化可诱导混合微凝胶，其可以进一步修改固定在微凝胶内的量子点的物理化学环境的可逆溶胀/收缩，从而导致可逆淬火/在光致发光（PL）antiquenching。该方法可延伸到与不同的发射波长和其他的靶向配体的量子点等，因此有可能开发的多功能混合微米/纳米凝胶为额外的重要的生物医学应用。

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