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首页> 外文会议>American Society For Engineering Education Annual Conference and Exposition >APPLYING MASS BALANCES TO ALCOHOL METABOLISM: A TEAM PROJECT THAT APPLIES FUNDAMENTAL CHEMICAL ENGINEERING SKILLS TO BIOTECHNOLOGY
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APPLYING MASS BALANCES TO ALCOHOL METABOLISM: A TEAM PROJECT THAT APPLIES FUNDAMENTAL CHEMICAL ENGINEERING SKILLS TO BIOTECHNOLOGY

机译：将质量平衡应用于酒精新陈代谢：一个将基本化学工程技能对生物技术应用的团队项目

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In the last decade, chemical engineering has evolved to meet the growing challenges of the 21st century, particularly in the areas of biotechnology and sustainable development. However, the chemical engineering curriculum has somewhat lagged in integrating and reflecting these modern topics. Approximately 30% of students entering our Mass and Energy Balances class list interests in biologically-related topics (pharmaceutical, biomedical, medical, environmental) versus about 10% each for industry, energy, research, and other, with 20% undecided, and about 10% non-respondents (mostly non-chemical engineering undergrads). This traditional gateway course needs to continually evolve to develop student awareness of the current issues, excite their interest in finding solutions to challenges that face their generation, and engage them in learning the required fundamental skills to find those solutions. Topics on biotechnology were absent in the course initially, and as we investigated ways to integrate these topics into the class we found that there was a paucity of published biochemical-themed projects for a sophomore-level mass balance curriculum. This challenged us to develop a new team project that incorporates biotechnology. We chose to apply mass balances to human alcohol metabolism. Student teams create a mass balance model of the breakdown of ethanol within the human body using computer spreadsheets to calculate mass flow rates to and from key organs. Process units model the organs handling biological functions such as oxygen and liquid intake, chemical breakdown, and waste removal. The project requires only knowledge of multi-unit mass balances and chemical reactions in the steady state; parameters are designed to create reasonable physiological results from their model. Students test their model using an established basis and monitor variables such as blood alcohol concentration and blood acetaldehyde concentration. Students investigate "Asian blush", a physiological syndrome resulting from different enzymatic degradation of ethanol in some Asian populations compared to those of European descent, thus introducing the students to human health issues. Students then scale their model from human proportions down to a microscale lab-on-a-chip device, a so-called "body-on-a-chip", which is an in vitro platform that is used for testing metabolic effects of various chemicals. With the premise of working as consultants for a pharmaceutical company, students study a fictional drug which is supposed to suppress alcoholism by artificially increasing alcohol sensitivity. Student groups are assigned different formulations, each altering different parameters in their mass balance model, and are asked to analyze the effects of their drug to determine its efficacy. Formulations can vary from detrimental to beneficial, requiring students to develop analytical skills and engineering judgment as they assess the drug performance. By combining computer technology and biochemical principles, we created a self-contained, group, project module which introduces students to a number of different biotechnological and human health issues, and develops critical thinking, team work, and communication skills. This project addresses students' professional interests, engages them in active learning, and reinforces the mass balance fundamentals that are building blocks for subsequent courses in the chemical engineering curriculum.
机译：在过去的十年中，化学工程已经发展，以满足21世纪的日益增长的挑战，特别是在生物技术和可持续发展领域。然而，化学工程课程在整合和反映了这些现代主题方面有点滞后。大约30％的学生进入大众和能量余额课程列表在生物学相关的主题（制药，生物医学，医疗，环境）与工业，能源，研究和其他人中约10％的兴趣，20％未定，以及约10％的非受访者（主要是非化学工程本科）。这种传统的门户课程需要不断发展，以发展学生对当前问题的认识，激励他们对面对他们这一代的挑战的解决方案，并从事学习所需的基本技能来找到这些解决方案的解决方案。最初在课程中缺席了生物技术的主题，并且当我们调查了将这些主题整合到课堂上的方法时，我们发现有缺乏出版的生物化学主题项目，用于学生级别平衡课程。这挑战我们开发一个包含生物技术的新团队项目。我们选择将质量平衡施加到人类酒精新陈代谢。学生团队使用计算机电子表格在人体内培养乙醇分解的质量平衡模型，以计算往返关键器官的质量流量。工艺单位模型器官处理生物功能，如氧气和液体摄入，化学分解和废物去除。该项目只需要在稳定状态下知识多单元质量平衡和化学反应;参数旨在从其模型创建合理的生理结果。学生使用建立的基础测试模型，并监测血液醇浓度和血液乙醛浓度等变量。学生们调查“亚洲腮红”，与欧洲血统的一些亚洲种群不同酶促降解的生理学综合征，从而将学生引入人类健康问题。然后学生将其模型从人类比例扩展到微观实验室内容，即所谓的“身体上芯片”，这是一种用于测试各种代谢效果的体外平台化学品。随着制药公司顾问的前提下，学生们研究了一个虚构的药物，它应该通过人工增加酒精敏感性来抑制酗酒。学生团体被分配不同的配方，每个配方都改变了他们的质量平衡模型中的不同参数，并被要求分析其药物的影响来确定其功效。配方可以因利益而异，要求学生开展分析技能和工程判断，因为它们评估了药物表现。通过组合计算机技术和生化原则，我们创建了一个独立的，集团，项目模块，将学生介绍了许多不同的生物技术和人类健康问题，并培养了批判性思维，团队工作和沟通技巧。该项目涉及学生的专业利益，从事主动学习，并加强了化学工程课程中随后课程的构建块的大规模平衡基础。

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