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首页> 外文会议>Portuguese Meeting in Bioengineering >Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers
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Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers

机译：细菌蛋白是一种新候选药物治疗未治疗的乳腺癌

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Azurin is a blue copper protein produced by Pseudomonas aeruginosa. Azurin enters preferentially into cancer cells and forms a complex with p53, stabilizing it and inducing apoptosis. Azurin allows in vivo regression of human melanoma and breast cancer without toxic effects to the animal. Its immunoglobulin-like fold and a large exposed hydrophobic patch confer on it the property of a natural scaffold. This has already been proven for the receptor tyrosine kinase EphB2, since azurin prevents its binding to the ligand ephrinB2. We intend to extend the azurin interaction to cell adhesion molecules (CAMs), particularly P-cadherin. P-cadherin is frequently overexpressed in invasive breast carcinomas and it is a poor prognosis marker. Protein-protein docking results have validated this approach confirming an interaction between both proteins. Thus, natural azurin or derived proteins or peptides could be scaffolds against these proteins in breast cancer cells models, being an interesting new therapeutic tool.
机译：硫林是由假单胞菌铜绿假单胞菌产生的蓝铜蛋白。硫酸素优先进入癌细胞，与p53形成复合物，稳定它并诱导细胞凋亡。硫林允许对人黑素瘤和乳腺癌的体内消退，对动物没有毒性作用。它的免疫球蛋白样折叠和大型暴露的疏水贴剂达到天然支架的性质。这已经被证明是对受体酪氨酸激酶EphB2，因为硫酸素防止其与配体EphrinB2的结合。我们打算将硫脲相互作用扩展到细胞粘附分子（凸轮），特别是p-cadherin。 P-Cadherin经常在侵袭性乳腺癌中过度表达，预测标志性差。蛋白质 - 蛋白对接结果已经验证了该方法证实两种蛋白质之间的相互作用。因此，天然硫林或衍生的蛋白质或肽可以是乳腺癌细胞模型中的这些蛋白质的支架，是一种有趣的新治疗工具。

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