首页> 外国专利> fusion protein, method for treating an individual who has a tumor, method for inhibiting angiogenesis in an individual, method for treating an individual who has ovarian cancer, method for treating an individual who has metabolic disorder, use of fusion protein, method for inhibiting physiological lymphangiogenesis or pathological lymphangiogenesis in an individual, method for inhibiting tumor metastasis in an individual, method for inhibiting the growth of a secondary tumor in an individual, method for inhibiting cooptation of a blood vessel by a tumor in an individual, Method To Treat An Individual's Breast Cancer

fusion protein, method for treating an individual who has a tumor, method for inhibiting angiogenesis in an individual, method for treating an individual who has ovarian cancer, method for treating an individual who has metabolic disorder, use of fusion protein, method for inhibiting physiological lymphangiogenesis or pathological lymphangiogenesis in an individual, method for inhibiting tumor metastasis in an individual, method for inhibiting the growth of a secondary tumor in an individual, method for inhibiting cooptation of a blood vessel by a tumor in an individual, Method To Treat An Individual's Breast Cancer

机译:融合蛋白,用于治疗具有肿瘤的个体的方法,用于抑制个体中血管生成的方法,用于治疗具有卵巢癌的个体的方法,用于治疗具有代谢紊乱的个体的方法,使用融合蛋白,用于抑制生理学的方法个体中的淋巴管生成或病理性淋巴管生成,抑制个体中肿瘤转移的方法,抑制个体中继发性肿瘤生长的方法,抑制个体中肿瘤导致的血管增生的方法,治疗个体的方法乳腺癌

摘要

This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.
机译:本发明提供了一种融合蛋白,其包含信号肽,EGF重复人Notch3受体蛋白的胞外域的1-X和其中结合的抗体的Fc部分,其中X是12至34的任何整数。本发明还提供治疗患有肿瘤的受试者的方法,抑制受试者的血管新生的方法,治疗患有卵巢癌的受试者的方法和治疗患有代谢异常的受试者的方法,包括对所述受试者给药有效治疗对象的上述融合蛋白的量。本发明进一步提供了上述融合蛋白在制备药物组合物中的用途,所述药物组合物用于治疗患有肿瘤的受试者,抑制受试者的血管新生,治疗患有卵巢癌的受试者以及用于治疗患有代谢的受试者。紊乱。

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