Effect of ion-pair formation with organic amines on transdermal penetration of lornoxicam in vitro

机译：离子对形成与有机胺对洛昔康体外透皮渗透的影响

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Purpose: The aim of this work was to investigate the percutaneous absorption of lornoxicam (LOX) with organic amines as counter-ions ; Methods: Various organic amines, diethylamine (DEtA), triethylamine (TEtA), triethanolamine (TEA), and N-(2'hydroxyethanol)-piperdine (NP), were investigated for promoting the passage of LOX through the rabbit skin in vitro. And ion pair formation between LOX and counter-ions was investigated in solution by IR and 'H-NMR spectroscopy ; Results: Ion pair formation had an obviously enhancing effect on LOX permeation ; Conclusion : These findings show that ion pair technique is an appropriate method for transdermal application of LOX.

机译：目的：这项工作的目的是探讨林昔康（LOX）与有机胺的经皮吸收作为反离子;方法：研究各种有机胺，二乙胺（DETA），三乙胺（TETA），三乙醇胺（茶）和N-（2'羟基乙醇）-PIPHERDINE（NP），用于促进LOX通过兔皮肤的体外通过。通过IR和'H-NMR光谱研究LOX和抗衡离子之间的离子对形成;结果：离子对形成对LOX渗透有明显增强;结论：这些研究结果表明，离子对技术是LOX透皮应用的适当方法。

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《Asian symposium on pharmaceutical sciences and technology》|2011年||共2页
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Honglei Xi; Lin Sun; Liang Fang;
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正文语种
中图分类药剂学;
关键词
Lornoxicam; Ion pair; Transdermal; IR; 'H-NMR;

机译：lornoxicam;离子对;透皮;IR;'H-NMR;

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专利

1. The relationship between hydrogen-bonded ion-pair stability and transdermal penetration of lornoxicam with organic amines [J] . XiH., WangZ., ChenY., European journal of pharmaceutical sciences . 2012,第2期

机译：氢键离子对稳定性与氯诺昔康与有机胺透皮渗透的关系
2. Ion-pair formation combined with a penetration enhancer as a dual strategy to improve the transdermal delivery of meloxicam [J] . Qikun Jiang, Jin Wang, Panqin Ma, Drug delivery and translational research . 2018,第1期

机译：离子对形成联合渗透增强剂作为改善美洛昔康透皮递送的双重策略
3. Effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide [J] . XiH., CunD., WangZ., International Journal of Pharmaceutics . 2012,第1a2期

机译：氢键离子对与有机胺的稳定性对特氟米特透皮渗透的影响
4. Effect of ion-pair formation with organic amines on transdermal penetration of lornoxicam in vitro [C] . Honglei Xi, Lin Sun, Liang Fang The Second Asian symposium on pharmaceutical sciences and technology . 2011

机译：有机胺形成离子对对氯诺昔康透皮渗透的影响
5. Effective screening of chemical penetration enhancers for transdermal drug delivery. [D] . Rachakonda, Vijay Krishna. 2008

机译：有效筛选化学渗透促进剂以进行透皮给药。
6. Lornoxicam controlled release transdermal gel patch: Design characterization and optimization using co-solvents as penetration enhancers [O] . Durriya Hashmat, Muhammad Harris Shoaib, Fatima Ramzan Ali, 2020

机译：氯诺昔康控释透皮凝胶贴剂：使用助溶剂作为渗透促进剂的设计表征和优化
7. Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers [O] . Durriya Hashmat, Muhammad Harris Shoaib, Fatima Ramzan Ali, 2020

机译：Lornoxicam控释透皮凝胶蛋白：使用共溶剂设计，表征和优化作为渗透增强剂

Effect of ion-pair formation with organic amines on transdermal penetration of lornoxicam in vitro

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