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首页> 外文会议>Asian symposium on pharmaceutical sciences and technology >High tablettability and good disintegration of novel poly(vinylalcohol-acrylic acid-methylmethacrylate) (POVACOAT(R)) as a granulation binder
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High tablettability and good disintegration of novel poly(vinylalcohol-acrylic acid-methylmethacrylate) (POVACOAT(R)) as a granulation binder

机译：新型聚（乙烯醇 - 丙烯酸 - 甲基丙烯酸甲酯）的高块性和良好的崩解）（POVACOAT（R））作为造粒粘合剂

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Purpose: POVACOAT is a newly developed aqueous polymer which is poly (vinyl alcohol) derivative grafted with acrylic acid and methyl methacrylate. POVACOAT is applied to coating film, granulation binder and solid dispersion carrier etc. This study was focused on the applicability as a granulation binder. Methods: In order to elucidate the wet granulation tendency of POVACOAT, the solid-liquidair packing states of wet massing were evaluated by a mixer torque rheometer (MTR). Hydroxypropylcellulose (HPC-L) was used for comparison. In the next step, the granules obtained with varying the binder liquid amounts were evaluated with regard to tablettability and disintegration. Results: Torque profiles by a MTR suggested that the amounts of POVACOAT as a binder liquid for obtaining the optimized tabletting granules were smaller than that of HPC-L. The tablettability which is defined as tablet hardness against tablet density with varying tabletting pressures was found to be superior in POVACOAT against HPC-L. The disintegration times of tablets were rather faster than that of HPC-L in spite of the higher tablet hardness. These results demonstrated that POVACOAT has an excellent performance as a wet granulation binder with a good balance between the tablettability and disintegration
机译：目的：povacoat是一种新开发的水性聚合物，其是聚（乙烯醇）衍生物与丙烯酸和甲基丙烯酸甲酯接枝。 POVACOAT施加到涂膜，造粒粘合剂和固体分散体的载体等，这研究都集中在适用性作为制粒粘合剂。方法：为了阐明POVACOAT的湿法制粒倾向，固体liquidair包装湿式块的状态是由一个混合器转矩流变仪（MTR）进行评价。羟丙基纤维素（HPC-L）用于比较。在下一步骤中，用不同的粘合剂液的量相对于tablettability和崩解进行评价得到的颗粒。结果：扭矩曲线由MTR建议POVACOAT的量作为用于获得优化的压片颗粒的粘合剂液体均高于HPC-L的小。其与不同的压片压力定义为片剂硬度对片剂密度tablettability被发现是在与HPC-L POVACOAT优异。片剂的崩解时间分别为而快于HPC-L的，尽管更高的片剂硬度的。这些结果表明，POVACOAT具有优良的性能与tablettability和解体之间的良好平衡湿法制粒粘合剂

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