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首页> 外文会议>The Second Asian symposium on pharmaceutical sciences and technology >High tablettability and good disintegration of novel poly(vinylalcohol-acrylic acid-methylmethacrylate) (POVACOAT(R)) as a granulation binder
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High tablettability and good disintegration of novel poly(vinylalcohol-acrylic acid-methylmethacrylate) (POVACOAT(R)) as a granulation binder

机译：新型聚（乙烯醇-丙烯酸-甲基丙烯酸甲酯）（POVACOAT®）作为制粒粘合剂的高压片性和良好的崩解性

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Purpose: POVACOAT is a newly developed aqueous polymer which is poly (vinyl alcohol) derivative grafted with acrylic acid and methyl methacrylate. POVACOAT is applied to coating film, granulation binder and solid dispersion carrier etc. This study was focused on the applicability as a granulation binder. Methods: In order to elucidate the wet granulation tendency of POVACOAT, the solid-liquidair packing states of wet massing were evaluated by a mixer torque rheometer (MTR). Hydroxypropylcellulose (HPC-L) was used for comparison. In the next step, the granules obtained with varying the binder liquid amounts were evaluated with regard to tablettability and disintegration. Results: Torque profiles by a MTR suggested that the amounts of POVACOAT as a binder liquid for obtaining the optimized tabletting granules were smaller than that of HPC-L. The tablettability which is defined as tablet hardness against tablet density with varying tabletting pressures was found to be superior in POVACOAT against HPC-L. The disintegration times of tablets were rather faster than that of HPC-L in spite of the higher tablet hardness. These results demonstrated that POVACOAT has an excellent performance as a wet granulation binder with a good balance between the tablettability and disintegration
机译：目的：POVACOAT是一种新开发的水性聚合物，是接枝丙烯酸和甲基丙烯酸甲酯的聚乙烯醇衍生物。 POVACOAT应用于涂膜，制粒粘合剂和固体分散体载体等。本研究的重点是作为制粒粘合剂的适用性。方法：为了阐明POVACOAT的湿法制粒趋势，通过混合器扭矩流变仪（MTR）评估了湿法成团的固液空气堆积状态。羟丙基纤维素（HPC-L）用于比较。在下一步中，对改变粘合剂液体量获得的颗粒的可压片性和崩解性进行评估。结果：MTR的扭矩曲线表明，POVACOAT作为获得最佳压片颗粒的粘合剂液体的量小于HPC-L。发现在POVACOAT中，压片性定义为压片硬度与压片密度随压片压力的变化，而压片性优于HPC-L。尽管片剂硬度较高，但片剂的崩解时间却比HPC-L快。这些结果表明，POVACOAT作为湿法制粒粘合剂具有出色的性能，在压片性和崩解性之间具有良好的平衡。

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