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首页> 外文会议>Asian symposium on pharmaceutical sciences and technology >Structure Determination of Acyclovir Cocrystals by Powder X-Ray Diffraction
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Structure Determination of Acyclovir Cocrystals by Powder X-Ray Diffraction

机译：粉末X射线衍射结构测定Acyclovir Cocrystals

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Purpose: To design and prepare cocrystals of acyclovir using crystal engineering approaches, with the ultimate objective of improving the physical properties of acyclovir. Materials and Methods: Various cocrystal formers including carboxylic acid, performed in order to obtain acyclovir cocrystals by cogrinding and slow evaporation methods. The potential cocrystalline phase was characterized by PXRD techniques. The acyclovirglutaric acid (hereafter ACV-GLU cocrystal) cocrystal structure and acyclovir-gentisic acid (hereafter ACV-GEN cocrystal) cocrystal structure were determined from powder X-ray diffraction data. Results: The ACV-GLU cocrystals were obtained by liquid-assisted cogrinding methods. The ACV-GEN cocrystals were obtained by slow evaporation. Conclusions: The cocrystal structures were determined by powder X-ray diffraction analysis.
机译：目的：利用晶体工程方法设计和准备Acyclovir的CocrystAls，具有改善Acyclovir的物理性质的最终目标。材料和方法：通过COGRINDING和缓慢蒸发方法进行羧酸，进行各种聚碳酸成型剂，以获得ACYCLOVIR COCRYALAL。潜在的COCRYSTALLINE相表征是PXRD技术。从粉末X射线衍射数据确定酰氯杂氟脲酸（以下，acv-glu Cocrystal）Cocrystal结构和Acyclovir-烯丙酸（以下，所述ACV-Gen Cocrystal）酰基结构。结果：通过液体辅助的Cogrinding方法获得ACV-Glu CocrystAls。通过缓慢蒸发获得ACV-Gen Cocrystals。结论：通过粉末X射线衍射分析测定COCRYSTAL结构。

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