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首页> 外文会议>The Second Asian symposium on pharmaceutical sciences and technology >Structure Determination of Acyclovir Cocrystals by Powder X-Ray Diffraction
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Structure Determination of Acyclovir Cocrystals by Powder X-Ray Diffraction

机译：粉末X射线衍射法测定阿昔洛韦共晶体的结构

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Purpose: To design and prepare cocrystals of acyclovir using crystal engineering approaches, with the ultimate objective of improving the physical properties of acyclovir. Materials and Methods: Various cocrystal formers including carboxylic acid, performed in order to obtain acyclovir cocrystals by cogrinding and slow evaporation methods. The potential cocrystalline phase was characterized by PXRD techniques. The acyclovirglutaric acid (hereafter ACV-GLU cocrystal) cocrystal structure and acyclovir-gentisic acid (hereafter ACV-GEN cocrystal) cocrystal structure were determined from powder X-ray diffraction data. Results: The ACV-GLU cocrystals were obtained by liquid-assisted cogrinding methods. The ACV-GEN cocrystals were obtained by slow evaporation. Conclusions: The cocrystal structures were determined by powder X-ray diffraction analysis.
机译：目的：使用晶体工程方法设计和制备阿昔洛韦的共晶体，最终目的是改善阿昔洛韦的物理性能。材料和方法：进行各种共晶形成剂，包括羧酸，以通过共研磨和慢速蒸发方法获得无环鸟苷共晶。潜在的共晶相通过PXRD技术表征。由粉末X射线衍射数据确定无环戊二酸（下文称为ACV-GLU共结晶）的共晶结构和无环戊二酸（下文称为ACV-GEN共结晶）的共晶结构。结果：采用液体辅助共研磨法得到ACV-GLU共晶。通过缓慢蒸发获得ACV-GEN共晶体。结论：通过粉末X射线衍射分析确定了共晶结构。

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