Visualizing and Identifying the DNA Methylation Markers in Breast Cancer Tumor Subtypes

机译：可视化和鉴定乳腺癌肿瘤亚型中的DNA甲基化标志物

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DNA methylation is an epigenetic mechanism that cells use to control gene expression. DNA methylation has become one of the hottest topics in cancer research, especially for abnormally hypermethylated tumor suppressor genes or hypomethylaed oncogenes research. The analysis of DNA methylation data determines the differential hypermethlated or hypomethylated genes that are candidate to be cancer biomarkers. Visualization the DNA methylation status may lead to discover new relationships between hypomethylated and hypermethylated genes, therefore this paper applied a mathematical modelling theory called formal concept analysis for visualizing DNA methylation status.

机译：DNA甲基化是一种表观遗传机制，即细胞用于控制基因表达。 DNA甲基化已成为癌症研究中最热门的主题之一，特别是对于异常高甲基化的肿瘤抑制基因或脱甲基型癌癌的研究。 DNA甲基化数据的分析决定了候选癌症生物标志物的差分高溶剂化或脱甲基化基因。可视化DNA甲基化状态可能导致脱甲基化和高甲基化基因之间的新关系，因此本文应用了一种称为正式概念分析的数学建模理论，用于可视化DNA甲基化状态。

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《International Conference on Innovations in Bio-inspired Computing and Applications》|2014年||共11页
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Islam Ibrahim Amin; Aboul Ella Hassanien; Hesham A. Hefny; and Samar K. Kassim;
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中图分类 TP18-532;
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DNA methylation; Epigenetic; hypomethylated genes; hypermethlated genes; Formal concept analysis.;

机译：DNA甲基化;表观遗传;低甲基化基因;高血栓化基因;正式的概念分析。;

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1. DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables [J] . Sitharthan Kamalakaran, Vinay Varadan, Hege E. Giercksky Russnes, Molecular oncology. . 2011,第1期

机译：管腔型乳腺癌中的DNA甲基化模式与非管腔型亚型不同，并且可以独立于其他临床变量确定复发风险
2. Identifying subtype-specific associations between gene expression and DNA methylation profiles in breast cancer [J] . Garam Lee, Lisa Bang, So Yeon Kim, BMC Medical Genomics . 2017,第1期

机译：鉴定乳腺癌基因表达与DNA甲基化谱之间的亚型特异性关联
3. Correction: Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity (Cancer Research (2011) 71, (2988-2999)) [J] . Noauthornameavailable Cancer research: The official organ of the American Association for Cancer Research, Inc . 2012,第12期

机译：更正：乳腺癌中CpG岛的全基因组DNA甲基化图谱鉴定了与致癌性相关的新基因（Cancer Research（2011）71，（2988-2999））
4. Visualizing and Identifying the DNA Methylation Markers in Breast Cancer Tumor Subtypes [C] . Islam Ibrahim Amin, Aboul Ella Hassanien, Hesham A. Hefny, International Conference on Innovations in Bio-inspired Computing and Applications . 2014

机译：可视化和鉴定乳腺癌肿瘤亚型中的DNA甲基化标志物
5. Investigation of dna and rna markers by novel technologies demonstrates DNA content intratumoral heterogeneity and long non-coding RNA aberrations in breast tumors [D] . Zhang, Zhouwei. 2014

机译：通过新技术对dna和rna标记物的研究表明，DNA含量在肿瘤中具有肿瘤内异质性和长期的非编码RNA畸变
6. DNA methylation patterns in luminal breast cancers differ from non‐luminal subtypes and can identify relapse risk independent of other clinical variables [O] . Sitharthan Kamalakaran, Vinay Varadan, Hege E. Giercksky Russnes, 2011

机译：管腔型乳腺癌的DNA甲基化模式不同于非管腔型的亚型并且可以独立于其他临床变量确定复发风险
7. Deconvolution of DNA methylation signatures identifies common differentially methylated gene regions on 1p36 across breast cancer subtypes [O] . Alexander J. Titus, Gregory P. Way, Kevin C. Johnson, 2017

机译：DNA甲基化签收的去卷积鉴定乳腺癌亚型1p36上的常见差异甲基化基因区

Visualizing and Identifying the DNA Methylation Markers in Breast Cancer Tumor Subtypes

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