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首页> 外文会议>Symposium on modern chiral pesticides: enantioselectivity and its consequences >Evaluating in Vivo Toxicity of Chiral Pesticides Using the Zebrafish (Danio rerio) Embryo Model
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Evaluating in Vivo Toxicity of Chiral Pesticides Using the Zebrafish (Danio rerio) Embryo Model

机译：使用Zebrafish（Danio Rerio）胚胎模型评估手性杀虫剂的体内毒性

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Enantioselectivity in toxicology of chiral pesticides has become one of the frontier topics facing toxicology. However, the toxicological data of chiral pesticides is in great scarcity. This is because of the different toxicological profiles between enantiomers and the racemates, and the dearth of enough enantiopure samples for toxicity assay. Zebrafish (Danio rerio) embryos provide an attractive model for determining the acute toxicity in relation to environmental risk assessment of chiral pesticides, offering the possibilities to perform small-scale, high-throughput analyses and less sample needs compared with other in vivo models. Beyond their application for determining acute toxicity, zebrafish embryos are also excellent models for understanding toxic mechanisms and the indication of possible adverse and long-term effects. Various applications of zebrafish embryos have been used for studying toxicogenomics, such as the effect of chemicals on gene and protein expression patterns. Other major possible applications include studies in metabolism, bioconcentration and biomarkers. These unique properties make them especially suitable for in vivo enantioselective toxicity assay of chiral pesticides.
机译：在对映选择性手性农药的毒性已成为毒理学面临的前沿课题之一。然而，手性农药的毒理学数据是巨大的稀缺性。这是因为对映体和外消旋体，和对映纯的足够样本的毒性分析的缺乏之间的不同的毒理学概况的。斑马鱼鱼（Danio rerio）胚胎，用于确定相对于手性农药的环境风险评估的急性毒性，将提供准备进行小规模提供吸引人的模型，高通量分析和较少的样品需要在体内模型进行比较。超出其用于确定急性毒性应用，斑马鱼的胚胎也用于理解毒性机制和可能的不利和长期影响的指示优良模型。斑马鱼胚胎的各种应用已经被用于研究毒理基因，如化学品对基因和蛋白表达模式的影响。其他主要可能的应用包括代谢，生物降解和生物标志物研究。这些独特的性质使它们特别适用于手性农药的体内对映选择性毒性分析。

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