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首页> 外文会议>International Symposium on Therapeutic Ultrasound (2002-) >Application of MR-guided focused pulsed ultrasound for destroying clots in vitro using thrombolytic drugs
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Application of MR-guided focused pulsed ultrasound for destroying clots in vitro using thrombolytic drugs

机译：MR-Guided Foced Pulsed超声在使用溶栓药物破坏凝块的应用

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In this paper an MR-guided focused pulsed ultrasound system for the treatment of stroke using thrombolytic drugs in a model in vitro is presented. A single element spherically focused transducer of 5 cm diameter; focusing at 10 cm and operating at 0.5 MHz or 1 MHz was used. The transducer was mounted in an MR compatible robot. The artery was modelled using a silicone tube. Tissue was modelled using polyaclylimide gel. Coagulated blood was used to model thrombus. A thermocouple was placed in the thrombus in order to measure the thrombus temperature. The effect of power, beam, and frequency was investigated. The goal was to maintain a temperature increase of less than 1 deg C during the application of pulse ultrasound (called safe temperature). With the application of ultrasound alone there was no notable destruction of the thrombus. With the combination of ultrasound and thrombolytic drugs destruction occurred after 60 mins of pulse exposure (PRF(velence)1 s, duty factor(velence)10percent, and with thrombus placed at 1 cm deep in the tissue). This simple in vitro model was proven very successful for evaluating MRgFUS as a modality for treating stroke. In the future we plan to apply this treatment protocol in live animals and humans.
机译：本文介绍了一种MR引导的聚焦脉冲超声系统，用于在体外模型中使用溶栓药物治疗中风。单个元件球形聚焦的换能器，直径为5厘米;聚焦在10厘米处并使用0.5MHz或1MHz。换能器安装在MR兼容机器人中。动脉使用硅树脂管进行建模。使用聚酰氯酰亚胺凝胶模拟组织。凝血血液用于模拟血栓。将热电偶放入血栓中以测量血栓温度。研究了功率，梁和频率的影响。目标是在施加脉冲超声（称为安全温度）期间维持低于1℃的温度升高。仅凭超声波的应用，血栓没有明显的破坏。随着超声和溶栓药物的组合在60分钟的脉冲暴露后发生（PRF（柔滑）1 s，占子因子（柔软）10％，血栓置于组织深处1cm）。这种简单的体外模型被证明非常成功，用于评估MRGFU作为治疗中风的态化。在未来，我们计划在活的动物和人类中应用此治疗方案。

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