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首页> 外文会议>International Mechanics of Hearing Workshop >Decreasing Outer Hair Cell Membrane Cholesterol Increases Cochlear Electromechanics
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Decreasing Outer Hair Cell Membrane Cholesterol Increases Cochlear Electromechanics

机译：减少外毛细胞膜胆固醇增加了耳蜗机电

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The effect of decreasing membrane cholesterol on the mechanical response of the cochlea to acoustic and/or electrical stimulation was monitored using laser interferometry. In contrast to pharmacological interventions that typically decrease cochlear electromechanics, reducing membrane cholesterol increased the response. The electromechanical response in untreated preparations was asymmetric with greater displacements in response to positive currents and cholesterol depletion increased the asymmetry. The results confirm that outer hair cell electromotility is enhanced by low membrane cholesterol. The asymmetry of the response indicates the outer hair cell resting membrane potential is hyperpolarized relative to the voltage of maximum gain for the outer hair cell voltage-displacement function. The magnitude of the response increase suggests a non-uniform distribution of cholesterol along the lateral wall of normal adult outer hair cells.
机译：使用激光干涉测量监测减少膜胆固醇对耳蜗对声学和/或电刺激的机械响应的影响。与通常减少耳蜗机电机械的药理学干预措施相反，还原膜胆固醇增加了响应。未处理制剂中的机电反应不对称，响应阳性电流和胆固醇耗尽增加不对称性。结果证实，通过低膜胆固醇增强外毛细胞电器。响应的不对称表示外毛细胞静止膜电位相对于外毛电池电压 - 位移函数的最大增益电压是超极化的。响应增加的幅度表明沿正常成体外毛细胞的侧壁胆固醇的不均匀分布。

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