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首页> 外文会议>International Conference on Advanced Design and Manufacturing Engineering >Manufacture of Ternary Solid Dispersions Composed of Nifedipine, Eudragit E and Adsorbent
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Manufacture of Ternary Solid Dispersions Composed of Nifedipine, Eudragit E and Adsorbent

机译：由硝苯地平，Eudragit E和吸附剂组成的三元固体分散体的制造

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The aim of this study was to manufacture the ternary solid dispersions composed of nifedipine, Eudragit E and adsorbent. Dissolution enhancement of nifedipine was also investigated. The inert solid carriers were added in the mixtures of nifedipine and Eudragit E at varying ratios. The physicochemical properties of ternary systems, compared to physical mixtures, were analyzed using powder x-ray diffraction (PXRD) and differential scanning calorimetry (DSC). The dissolution of nifedipine from ternary systems was compared to the drug alone. The influence of drug:polymer: adsorbent ratio and type of adsorbent on the dissolution rate of the drug was also evaluated. The PXRD and DSC results of the systems with high amount of polymer showed that the drug was present in an amorphous form. On the other hand, the diffraction patterns and DSC thermograms of the physical mixtures revealed that to some extent the drug was present in a crystalline form. The results from this study demonstrated that an improvement in dissolution rate of nifedipine with Eudragit E and adsorbents was obtained.
机译：本研究的目的是制造由硝苯地平，Eudragit E和吸附剂组成的三元固体分散体。还研究了硝苯地平的溶解增强。在不同比率下在硝苯地平和Eudragit E的混合物中加入惰性固体载体。使用粉末X射线衍射（PXRD）和差示扫描量热法（DSC）分析与物理混合物相比的三元系统的物理化学性质。单独将硝苯地平从三元体系中的溶解与单独的药物进行比较。还评价了药物：聚合物的影响：聚合物：吸附剂比和吸附剂对药物溶出速率的影响。具有大量聚合物的系统的PXRD和DSC结果表明该药物以无定形形式存在。另一方面，物理混合物的衍射图案和DSC热图揭示了在某种程度上，药物以结晶形式存在。本研究的结果证明，获得了与Eudragit E和吸附剂的硝苯地平溶出速率的提高。

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