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Recent Advances in the Bioactivities and Structural Analysis of Chondroitin Sulfate

机译:硫酸软骨素的生物活性和结构分析的最新进展

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Recent research data on chondroitin sulfate have suggested that they have many new biological functions such as anti-atherogenesis, anticoagulation, prevention and cure of arthritis, protection and repair of neuron during CNS development, morphogenesis and cell division. They are widely applied to functional food, clinical medicine and biomaterial. However, these bioactivities and applications are dependent on their fine structure with different monosaccharide unit and sulfation patterns. This review provides information on intimate relationship between these biological functions and the structure. Moreover, we overviewed the newly analytical methods about the composition and fine structure of them, including chromatometry, high performance liquid chromatography, mass spectrum and nuclear magnetic resonance before and after enzymolysis.
机译:最近关于软骨素硫酸盐的研究数据表明,它们具有许多新的生物学功能,例如抗血肿,抗凝,预防和治愈关节炎,神经元在CNS发育期间的保护和修复,形态发生和细胞分裂。它们广泛应用于功能性食品,临床医学和生物材料。然而,这些生物活化性和应用依赖于其具有不同单糖单元和硫化模式的细结构。本次审查提供了有关这些生物功能与结构之间的亲密关系的信息。此外,我们概述了关于它们的组成和细结构的新分析方法,包括酶解前后和之后的色谱法,高性能液相色谱,质谱和核磁共振。

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