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Characteristics of Voxel Prediction Power in Full-brainGranger Causality Analysis of fMRI Data

机译:FMRI数据全BraingRanger因果区分析中体素预测功率的特征

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Functional neuroimaging research is moving from the study of "activations" to the study of "interactions" among brain regions. Granger causality analysis provides a powerful technique to model spatio-temporal interactions among brain regions. We apply this technique to full-brain fMRI data without aggregating any voxel data into regions of interest (ROIs). We circumvent the problem of dimensionality using sparse regression from machine learning. On a simple finger-tapping experiment we found that (1) a small number of voxels in the brain have very high prediction power, explaining the future time course of other voxels in the brain; (2) these voxels occur in small sized clusters (of size 1-4 voxels) distributed throughout the brain; (3) albeit small, these clusters overlap with most of the clusters identified with the non-temporal General Linear Model (GLM); and (4) the method identifies clusters which, while not determined by the task and not detectable by GLM, still influence brain activity.
机译:功能性神经影像学研究正在从“激活”研究到脑区“相互作用”研究。格兰杰因果区分析提供了一种强大的技术,可以在大脑区域之间模拟时空相互作用。我们将该技术应用于全脑FMRI数据,而不会将任何体素数据汇总到兴趣区域(ROI)。我们使用从机器学习的稀疏回归来规避维度的问题。在简单的手指攻丝实验中,我们发现(1)大脑中少量的体素具有非常高的预测能力,解释了大脑中其他体素的未来时间过程; (2)这些体素发生在整个大脑中分布的小尺寸簇(大小1-4体素); (3)尽管小,这些簇与大多数用非时间通用线性模型(GLM)识别的大多数集群重叠; (4)该方法识别群集,而不是由任务确定而不确定的,而不是通过GLM检测到的,仍然影响脑活动。

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